Toggle Main Menu Toggle Search

Open Access padlockePrints

Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor Imaging and fast marching tractography

Lookup NU author(s): Klaas Stephan

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Diffusion tensor imaging (DTI), a magnetic resonance imaging technique, is used to infer major axonal projections in the macaque and human brain. This study investigates the feasibility of using known macaque anatomical connectivity as a "gold-standard" for the evaluation of DTI tractography methods. Connectivity information is determined from the DTI data using fast marching tractography (FMT), a novel tract-tracing (tractography) method. We show for the first time that it is possible to determine, in an entirely noninvasive manner, anatomical connection pathways and maps of an anatomical connectivity metric in the macaque brain using a standard clinical scanner and that these pathways are consistent with known anatomy. Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed. (C) 2002 Elsevier Science (USA).


Publication metadata

Author(s): Parker GJM, Stephan KE, Barker GJ, Rowe JB, MacManus DG, Wheeler-Kingshott CAM, Ciccarelli O, Passingham RE, Spinks RL, Lemon RN, Turner R

Publication type: Article

Publication status: Published

Journal: NeuroImage

Year: 2002

Volume: 15

Issue: 4

Pages: 797-809

ISSN (print): 1053-8119

ISSN (electronic): 1095-9572

Publisher: Academic Press

URL: http://dx.doi.org/10.1006/nimg.2001.0994

DOI: 10.1006/nimg.2001.0994


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
077029Wellcome Trust
491Multiple Sclerosis Society

Share