Toggle Main Menu Toggle Search

Open Access padlockePrints

APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division

Lookup NU author(s): Dr Alexandra Reis, Dr Mark Levasseur, Professor Keith Jones

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Fully grown mammalian oocytes maintain a prophase I germinal-vesicle stage arrest in the ovary for extended periods before a luteinizing hormone surge induces entry into the first meiotic division. Cdh1 is an activator of the anaphase-promoting complex (APC) and APC(cdh1) is normally restricted to late M to early G1 phases of the cell cycle. Here, we find that APC(cdh1) is active in mouse oocytes and is necessary to maintain prophase arrest.


Publication metadata

Author(s): Reis A, Chang HY, Levasseur M, Jones KT

Publication type: Article

Publication status: Published

Journal: Nature Cell Biology

Year: 2006

Volume: 8

Issue: 5

Pages: 539-540

ISSN (print): 1465-7392

ISSN (electronic): 1476-4679

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/ncb1406

DOI: 10.1038/ncb1406


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
065354Wellcome Trust
075744Wellcome Trust

Share