ePrints

Invasive aspergillosis of the small bowel in an infant with acute myeloid leukemia and intestinal obstruction

Lookup NU author(s): Dr James Hayden, Dr Katrina Wood, Professor Roderick Skinner

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Acute myeloid leukemia was diagnosed in an infant with fever and pancytopenia. Intestinal obstruction was present at diagnosis and laparotomy performed after failure of conservative management demonstrated leukemic infiltration of the resected terminal ileum. Fever and intestinal obstruction persisted, necessitating a second ileal resection, which revealed invasive aspergillosis. Subsequent retrospective analysis identified occasional fungal hyphae in the initial resection specimen. With the combination of intensive chemotherapy and aggressive prolonged antifungal therapy the child survived. Invasive aspergillosis may unusually present at nonpulmonary sites at initial presentation of acute leukemia. Microbiological or histological diagnosis is needed to guide aggressive appropriate management.

Publication metadata

Author(s): Hayden JT, Wood KM, Pedler S, Lawson A, Skinner R

Publication type: Article

Publication status: Published

Journal: Pediatric Hematology and Oncology

Year: 2009

Volume: 26

Issue: 1

Pages: 84-91

Print publication date: 01/01/2009

ISSN (print): 0888-0018

ISSN (electronic): 1521-0669

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.1080/08880010802625399

DOI: 10.1080/08880010802625399

Altmetrics

Share