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Dietary vitamin E, brain redox status and expression of Alzheimer's disease-relevant genes in rats

Lookup NU author(s): Dr Patricia Huebbe, Dr Christine Bosch-Saadatmandi

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Abstract

Oxidative stress is one of the major pathological features of Alzheimer's disease (AD). Here, we investigated whether dietary vitamin E (VE) depletion may induce adverse effects and supplementation with α-tocopherol (αT) may result in beneficial effects on redox status and the regulation of genes relevant in the pathogenesis of AD in healthy rats. Three groups of eight male rats each were fed diets with deficient ( < 1 mg αT equivalents/kg diet), marginal (9 mg αT equivalents/kg diet) or sufficient (18 mg αT equivalents/kg diet) concentrations of natural-source VE for 6 months; a fourth group was fed the VE-sufficient diet fortified with αT (total VE, 146 mg αT equivalents/kg diet). Feeding of the experimental diets dose dependently altered αT concentrations in the cortex and plasma. No significant changes in F2-isoprostane concentrations, activities of antioxidative enzymes (total superoxide dismutase, Se-dependent glutathione peroxidase) and concentrations of glutathione or the expression of AD-relevant genes were observed. In this non-AD model, depletion of VE did not induce adverse effects and supplementation of αT did not induce positive effects on the parameters related to the progression of AD.

Publication metadata

Author(s): Huebbe P; Boesch-Saadatmandi C; Gaedicke S; Zhang X; Lou Y; Wiswedel I; Gardemann A; Frank J; Rimbach G

Publication type: Article

Publication status: Published

Journal: British Journal of Nutrition

Year: 2009

Volume: 102

Issue: 3

Pages: 398-406

Date deposited: 29/06/2012

ISSN (print): 0007-1145

ISSN (electronic): 1475-2662

Publisher: Cambridge University Press

URL: http://dx.doi.org/10.1017/S000711450819122X

DOI: 10.1017/S000711450819122X

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