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Dynamic Covalent Single-Chain Polymer Nanoparticles

Lookup NU author(s): Dr Ben Murray, Dr David Fulton

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Abstract

Polymeric nanoparticles were prepared through the chain collapse of linear polymers driven by the formation of dynamic covalent bonds. Linear chains of poly(vinylbenzaldehyde) were intramolecularly cross-linked through the formation of dynamic covalent acylhydrazone bonds with a bis-hydrazide cross-linker. The cross-linking density was shown to be controlled by the amount of crosslinker used. The resulting single polymer chain nanoparticles were then adorned through reaction of their remaining aldehyde units with a series of monoacyl hydrazides or alkoxyamines. Alternatively, the linear polymer chains could be fully adorned by reaction of their aldehyde units with the monoacyl hydrazides and then intramolecularly cross-linked through exchange reactions with the bis-hydrazide cross-linker. Both approaches proved effective routes to prepare single-chain polymer nanoparticles possessing high functional density.


Publication metadata

Author(s): Murray BS, Fulton DA

Publication type: Article

Publication status: Published

Journal: Macromolecules

Year: 2011

Volume: 44

Issue: 18

Pages: 7242-7252

Print publication date: 02/09/2011

ISSN (print): 0024-9297

ISSN (electronic): 1520-5835

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/ma201331f

DOI: 10.1021/ma201331f


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