Browse by author
Lookup NU author(s): Dr Roslyn Simms, David Talbot, Dr Suren Kanagasundaram
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
We report a case of a 67-year-old man who experienced allograft dysfunction following a renal transplantation from a donation after cardiac death. The postoperative course was initially complicated by episodes of E. coli urinary sepsis causing pyrexia and a raised creatinine level. Ultrasound scanning 5 weeks posttransplant revealed mild hydronephrosis with several parenchymal cystic areas measuring up to 2 cm with appearances suggestive of fungal balls. Aspirated fluid again grew Escherichia coli, and this was treated with the appropriate antimicrobial therapy. The patient continued to have episodes of culture-negative sepsis; therefore, a computed tomography scan was performed 6 months posttransplant, which revealed multiple lesions in the renal cortex as well as liver and spleen. Subsequent biopsy revealed an EpsteinBarr virus-driven lymphoproliferation consistent with a polymorphic posttransplantation lymphoproliferative disorder (PTLD). This rare case of PTLD presenting as multiple renal, hepatic and splenic lesions emphasizes the need for a high index of clinical suspicion for this condition. Abnormal para-renal allograft masses should be biopsied to allow swift and effective management of a disease that can disseminate and become significantly more challenging to manage.
Author(s): Moir JAG, Simms RJ, Wood KM, Talbot D, Kanagasundaram NS
Publication type: Article
Publication status: Published
Journal: American Journal of Transplantation
Year: 2012
Volume: 12
Issue: 1
Pages: 245-249
Print publication date: 13/01/2012
ISSN (print): 1600-6135
ISSN (electronic): 1600-6143
Publisher: Wiley-Blackwell Publishing, Inc.
URL: http://dx.doi.org/10.1111/j.1600-6143.2011.03761.x
DOI: 10.1111/j.1600-6143.2011.03761.x
Altmetrics provided by Altmetric
