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Lookup NU author(s): Dr Gary Reynolds, Dr Faye Cooles, Professor John IsaacsORCiD, Professor Catharien Hilkens
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Novel treatments in development for rheumatoid arthritis target 3 broad areas: cytokines, cells, and signaling pathways. Therapies from each domain share common advantages (for example previously demonstrated efficacy, potential long-term immunomodulation, and oral administration respectively) that have stimulated research in each area but also common obstacles to their development. In this review recent progress in each area will be discussed alongside the factors that have impeded their path to clinical use.
Author(s): Reynolds G, Cooles FAH, Isaacs JD, Hilkens CMU
Publication type: Review
Publication status: Published
Journal: Human Vaccines & Immunotherapeutics
Year: 2014
Volume: 10
Issue: 4
Pages: 822-837
Print publication date: 17/02/2014
ISSN (print): 2164-5515
ISSN (electronic): 2164-554X
Publisher: LANDES BIOSCIENCE
URL: http://dx.doi.org/10.4161/hv.27910
DOI: 10.4161/hv.27910
