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Lookup NU author(s): Dr Jill McKay, Dr Alexandra Groom, Professor Dianne Ford, Lisa Coneyworth, Professor John Mathers, Professor Caroline Relton
This study examines the relationship between common genetic variation within DNA methyltransferase genes and inter-individual variation in DNA methylation. Eleven polymorphisms spanning DNMT1 and DNMT3B were genotyped. Global and gene specific (IGF2, IGFBP3, ZNT5) DNA methylation was quantified by LUMA and bisulfite Pyrosequencing assays, respectively, in neonatal cord blood and in maternal peripheral blood. Associations between maternal genotype and maternal methylation (n approximate to 333), neonatal genotype and neonatal methylation (n approximate to 454), and maternal genotype and neonatal methylation (n approximate to 137) were assessed. The findings of this study provide some support to the hypothesis that genetic variation in DNA methylating enzymes influence DNA methylation at global and gene-specific levels; however observations were not robust to correction for multiple testing. More comprehensive analysis of the influence of genetic variation on global and site specific DNA methylation is warranted.
Author(s): Potter C, McKay J, Groom A, Ford D, Coneyworth L, Mathers JC, Relton CL
Publication type: Article
Publication status: Published
Journal: PLoS ONE
Year: 2013
Volume: 8
Issue: 10
Online publication date: 01/10/2013
Acceptance date: 27/08/2013
Date deposited: 18/11/2014
ISSN (electronic): 1932-6203
Publisher: Public Library of Science
URL: http://dx.doi.org/10.1371/journal.pone.0076506
DOI: 10.1371/journal.pone.0076506
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