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Immunosuppressive drugs and fetal outcome

Lookup NU author(s): Emeritus Professor John Davison

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Abstract

Successful pregnancies have been reported in all types of solidorgan transplant recipients on a variety of immunosuppressive regimens. Immunosuppression is essential to maintain the transplanted organ and maternal health, thus the safety of these medications continues to be studied. This article reviews information in the literature and data from the National Trans-, plantation Pregnancy Registry (NTPR) in the United States related to immunosuppressive medication and pregnancy. Although most maintenance immunosuppressive regimens have not been shown to affect the outcome of posttransplant pregnancies, mycophenolic acid products are associated with an increased incidence of spontaneous abortion and an increase in the incidence and a specific pattern of birth defects. When counseling transplant recipients about the prospect and safety of pregnancy, the health of the mother, her graft, and the developing fetus must all be taken into account. (C) 2014 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Coscia LA, Constantinescu S, Davison JM, Moritz MJ, Armenti VT

Publication type: Article

Publication status: Published

Journal: Best Practice & Research Clinical Obstetrics & Gynaecology

Year: 2014

Volume: 28

Issue: 8

Pages: 1174-1187

Print publication date: 01/11/2014

Online publication date: 07/08/2014

ISSN (print): 1521-6934

ISSN (electronic): 1532-1932

Publisher: ELSEVIER SCI LTD

URL: http://dx.doi.org/10.1016/j.bpobgyn.2014.07.020

DOI: 10.1016/j.bpobgyn.2014.07.020

PubMed id: 25175414

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