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Mitochondrial-targeted antioxidants

Lookup NU author(s): Dr Anne Oyewole, Professor Mark Birch-MachinORCiD

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Abstract

Redox homeostasis is maintained by the antioxidant defense system, which is responsible for eliminating a wide range of oxidants, including reactive oxygen species (ROS), lipid peroxides, and metals. Mitochondrial (mt)-localized antioxidants are widely studied because the mitochondria; the major producer of intracellular ROS, has been linked to the cause of aging and other chronic diseases. Mt-targeted antioxidants have shown great potential because they cross the mt phospholipid bilayer and eliminate ROS at the heart of the source. Growing evidence has identified mt-targeted antioxidants, such as MitoQ and tiron as potentially effective antioxidant therapies against the damage caused by enhanced ROS generation. This literature review summarizes the current knowledge on mt-targeted antioxidants and their contribution to the body's antioxidant defense system. In addition to addressing the concerns surrounding current antioxidant strategies, including difficulties in targeting antioxidant treatment to sites of pathologic oxidative damage, we discuss promising therapeutic agents and new strategic approaches.-Oyewole, A. O., Birch-Machin, M. A. Mitochondrial-targeted antioxidants.

Publication metadata

Author(s): Oyewole A, Birch-Machin MA

Publication type: Review

Publication status: Published

Journal: FASEB Journal

Year: 2015

Volume: 29

Issue: 12

Pages: 4766-4771

Print publication date: 01/12/2015

Online publication date: 07/08/2015

Acceptance date: 03/08/2015

ISSN (print): 0892-6638

ISSN (electronic): 1530-6860

URL: http://dx.doi.org/10.1096/fj.15-275404

DOI: 10.1096/fj.15-275404

PubMed id: 26253366

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