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Tribbles and arthritis: what are the links?

Lookup NU author(s): Emeritus Professor Drew Rowan, Dr Gary Litherland

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Abstract

The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction pathways. In the arthritides, inflammation and a wide variety of pro-inflammatory pathways have been implicated to drive the cartilage destruction and consequent disability associated with both rheumatoid arthritis (RA) and osteoarthritis (OA). Despite burgeoning evidence linking the TRIB to inflammation-related pathologies such as diabetes, multiple sclerosis and cancer, very little is known about their roles in arthritis. The present review discusses current knowledge of the impact of TRIB on pro-inflammatory cellular mechanisms and pathways known to be important in the pathogenesis of RA and OA.

Publication metadata

Author(s): Rowan AD, Litherland GJ

Publication type: Article

Publication status: Published

Journal: Biochemical Society Transactions

Year: 2015

Volume: 43

Issue: 5

Pages: 1051-1056

Print publication date: 09/10/2015

Acceptance date: 01/01/1900

ISSN (print): 0300-5127

ISSN (electronic): 1470-8752

Publisher: Portland Press Ltd.

URL: http://dx.doi.org/10.1042/BST20150076

DOI: 10.1042/BST20150076

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