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Lookup NU author(s): Dr Stella Paddick, Dr Catherine DotchinORCiD, Professor Richard Walker
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Methods: during Phase I of the prevalence study, 1,198 people aged 70 years and over were screened, and a stratified sample of 296 was assessed for the presence of dementia or MCI in Phase II. Seventy-eight people had dementia and 46 had MCI. Four years after diagnosis, we attempted to follow-up all those seen in Phase II and record all deaths.Results: of the 296, follow-up data were available for 287 (97.0%), including 77 with dementia and 45 with MCI. Of the 172 with no cognitive impairment, 165 (95.9%) were followed up and a sample of 89 people selected as representative of the background population. Forty-eight people with dementia (62.3%), 19 with MCI (42.2%) and 11 with no cognitive impairment (12.4%) had died at 4-year follow-up. After adjusting for the effects of age, gender and education, the hazard ratio was 6.33 (95% CI 3.19-12.58) for dementia and 3.57 (95% CI 1.64-7.79) for MCI relative to people with no cognitive impairment. Mortality rates were highest in those with vascular dementia.Conclusion: dementia and MCI were associated with excess mortality relative to those with no cognitive impairment.
Author(s): Paddick SM, Kisoli A, Dotchin CL, Gray WK, Chaote P, Longdon A, Walker RW
Publication type: Article
Publication status: Published
Journal: Age and Ageing
Year: 2015
Volume: 44
Issue: 4
Pages: 636-641
Print publication date: 01/07/2015
Online publication date: 26/04/2015
Acceptance date: 31/12/2014
ISSN (print): 0002-0729
ISSN (electronic): 1468-2834
Publisher: Oxford University Press
URL: http://dx.doi.org/10.1093/ageing/afv048
DOI: 10.1093/ageing/afv048
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