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AimsWe wished to assess the feasibility of a future randomised controlled trial of parathyroid hormone (PTH) supplements to aid healing of trochanteric fractures of the hip, by an open label prospective feasibility and pilot study with a nested qualitative sub study. This aimed to inform the design of a future powered study comparing the functional recovery after trochanteric hip fracture in patients undergoing standard care, versus those who undergo administration of subcutaneous injection of PTH for six weeks.Patients and MethodsWe undertook a pilot study comparing the functional recovery after trochanteric hip fracture in patients 60 years or older, admitted with a trochanteric hip fracture, and potentially eligible to be randomised to either standard care or the administration of subcutaneous PTH for six weeks. Our desired outcomes were functional testing and measures to assess the feasibility and acceptability of the study.ResultsA total of 724 patients were screened, of whom 143 (20%) were eligible for recruitment. Of these, 123 were approached and 29 (4%) elected to take part. However, seven patients did not complete the study. Compliance with the injections was 11 out of 15 (73%) showing the intervention to be acceptable and feasible in this patient population.
Author(s): Chesser TJS, Fox R, Harding K, Halliday R, Barnfield S, Willett K, Lamb S, Yau C, Javaid MK, Gray AC, Young J, Taylor H, Shah K, Greenwood R
Publication type: Article
Publication status: Published
Journal: Bone & Joint Journal
Year: 2016
Volume: 98B
Issue: 6
Pages: 840-845
Print publication date: 01/06/2016
Online publication date: 27/05/2016
Acceptance date: 12/01/2016
ISSN (print): 2049-4394
ISSN (electronic): 2049-4408
Publisher: British Editorial Society of Bone and Joint Surgery
URL: http://dx.doi.org/10.1302/0301-620X.98B6.36794
DOI: 10.1302/0301-620X.98B6.36794
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