ePrints

A parametric study of the effect of arterial wall curvature on non-invasive assessment of stenosis severity: computational fluid dynamics study

Lookup NU author(s): Dr Girish Viswanathan

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

The effect of coronary arterial wall curvature on non-invasive assessment of stenosis severity was studied by examining the fractional flow reserve (FFR), pressure drop coefficient (CDP) and lesion flow coefficient (LFC) under different angles of curvature of the arterial wall models. Computational simulation of hyperemic blood flow in curved arteries with different angles of curvature (0 degrees, 30 degrees, 60 degrees, 90 degrees and 120 degrees) was developed in three severe categories of stenosis of 70% (moderate), 80% (intermediate), and 90% (severe) area stenoses (AS) to evaluate the effect of curvature on FFR, CDP and LFC. The numerical study showed that for a given percentage of AS, the curvature of the arterial wall augmented the flow resistance in addition to the resistance caused by the stenosis. Also, there are significant differences in FFR, CDP and LFC between a straight and a curved section. With an increase in artery wall curvature from 0 degrees to 120 degrees, FFR significantly decreases by 5%, 8% and 20% in 70%, 80% and 90% AS respectively. For a fixed stenosis severity, CDP significantly increases, whereas LFC decreases as the angle of curvature changes from straight to curved section. We conclude that the significant differences in FFR, CDP and LFC confirms that the functional significance of stenosis assessed non-invasively could lead to misjudgment of its severity. This will notably influence the intermediate stenosis severity. So the arterial wall curvature should be considered when assessing the significance of stenosis as an alternative to FFR.

Publication metadata

Author(s): Govindaraju K, Viswanathan GN, Badruddin IA, Kamangar S, Ahmed NJS, Al-Rashed AAAA

Publication type: Article

Publication status: Published

Journal: Current Science

Year: 2016

Volume: 111

Issue: 3

Pages: 483-491

Print publication date: 10/08/2016

Acceptance date: 01/01/1900

ISSN (print): 0011-3891

Publisher: Scientific Publishers

URL: http://www.currentscience.ac.in/Volumes/111/03/0483.pdf

DOI: 10.18520/cs/v111/i3/483-491

Altmetrics

Funding

Share