Metabolomics and nutritional challenge tests: What can we learn?

Brennan, L

doi:10.1016/B978-1-78242-084-2.00010-1

Metabolomics and nutritional challenge tests: What can we learn?

Lookup NU author(s): Professor Lorraine Brennan

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Abstract

© 2015 Elsevier Ltd. All rights reserved. Traditionally, metabolomics in nutrition research is applied to fasting samples, and while such an approach has been successful, a number of studies are beginning to emerge where metabolomics has been applied to the time course of a dietary challenge study. Analysing such dynamic metabolomic data has been successful on two fronts: (1) identifying metabolic phenotypes in the predisease state and (2) identifying subtle metabolic changes following dietary interventions. This chapter gives an overview of the key studies to date with a focus on human studies.