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Bronchiectasis and Aspergillus: How are they linked?

Lookup NU author(s): Professor Anthony De SoyzaORCiD

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Abstract

© 2016 The Author. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology. All rights reserved. Bronchiectasis is a chronic airway infection syndrome, distinct from cystic fibrosis that is rising in prevalence and is associated with significant morbidity and mortality. It can be caused by many etiologies including post-infectious effects or be seen in common lung diseases such as chronic obstructive pulmonary disease (COPD) or severe asthma. Bronchiectasis is associated with many Aspergillus-associated syndromes: allergic bronchopulmonary aspergillosis (ABPA)may complicate asthma, thus leading to bronchiectasis as part of the diagnostic criteria of ABPA or can complicate preexisting bronchiectasis due to another etiology. Aspergilloma can develop in areas of lung damage seen in patients with bronchiectasis, whereas fungal bronchitis may lead to later bronchiectasis. Invasive aspergillosis, perhaps more commonly viewed as a consequence of significant immunosuppression, is also seen in the absence of immunosuppression in those with underlying lung diseases including bronchiectasis. The pathogenesis and treatments of these diverse Aspergillus-associated diseases in bronchiectasis are discussed.

Publication metadata

Author(s): De Soyza A, Aliberti S

Publication type: Article

Publication status: Published

Journal: Medical Mycology

Year: 2017

Volume: 55

Issue: 1

Pages: 69-81

Online publication date: 28/10/2016

Acceptance date: 05/10/2016

ISSN (print): 1369-3786

ISSN (electronic): 1460-2709

Publisher: Oxford University Press

URL: https://doi.org/10.1093/mmy/myw109

DOI: 10.1093/mmy/myw109

PubMed id: 27794529

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