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Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges

Lookup NU author(s): Professor Moein MoghimiORCiD

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Abstract

© 2015 American Chemical Society.Dendrimers are three-dimensional macromolecular structures originating from a central core molecule and surrounded by successive addition of branching layers (generation). These structures exhibit a high degree of molecular uniformity, narrow molecular weight distribution, tunable size and shape characteristics, as well as multivalency. Collectively, these physicochemical characteristics together with advancements in design of biodegradable backbones have conferred many applications to dendrimers in formulation science and nanopharmaceutical developments. These have included the use of dendrimers as pro-drugs and vehicles for solubilization, encapsulation, complexation, delivery, and site-specific targeting of small-molecule drugs, biopharmaceuticals, and contrast agents. We briefly review these advances, paying particular attention to attributes that make dendrimers versatile for drug formulation as well as challenging issues surrounding the future development of dendrimer-based medicines.

Publication metadata

Author(s): Wu L-P, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM

Publication type: Review

Publication status: Published

Journal: Bioconjugate Chemistry

Year: 2015

Volume: 26

Issue: 7

Pages: 1198-1211

Online publication date: 05/02/2015

Acceptance date: 01/01/1900

ISSN (print): 1043-1802

ISSN (electronic): 1520-4812

Publisher: American Chemical Society

URL: https://doi.org/10.1021/acs.bioconjchem.5b00031

DOI: 10.1021/acs.bioconjchem.5b00031

PubMed id: 25654320

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