Summary and conclusions

Reeve, AK

doi:10.1007/978-3-319-28637-2_16

Summary and conclusions

Lookup NU author(s): Dr Amy Reeve

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Abstract

© Springer International Publishing 2016. All rights reserved. More than a decade of research has pushed forward our understanding of the changes that occur within neurons in neurodegenerative disease. From a mitochondrial point of view, we now know that mitochondrial DNA, reactive oxygen species, calcium handling, mitochondrial turnover, movement, neuronal localisation and dynamics are important for neuronal survival. It would seem feasible, therefore, that dysfunction in this organelle will have huge implications for the pathogenesis of a number of degenerative diseases. While we still have much to discover and understand with regard to the causes of these diseases, research in the field of mitochondrial dysfunction can only add to our understanding and hopes for therapeutic interventions.