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Lookup NU author(s): Libby Wood, Dr Nikoletta Nikolenko, Professor Hanns Lochmuller
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© 2017 Wiley Periodicals, Inc. Introduction: In light of recent evidence indicating that cancer is part of the myotonic dystrophy (DM) phenotype, we assessed the prevalence of benign and malignant tumors among 220 patients enrolled in the UK Myotonic Dystrophy Patient Registry and evaluated factors associated with their development. Methods: A survey was distributed to collect tumor history and lifestyle information. We used multinomial logistic regression for the analysis. Results: Thirty-nine benign (30 patients), and 16 malignant (15 patients) tumors were reported. Increasing age (odds ratio [OR] = 1.13, 95% confidence interval [CI] = 1.05–1.21, P = 0.001) and earlier age at DM diagnosis (OR = 1.06, 95% CI = 1.00–1.13, P = 0.04) were associated with benign and malignant tumors (OR = 1.20, 95% CI = 1.10–1.30, P < 0.001 and OR = 1.08, 95% CI = 1.01–1.15, P = 0.02, respectively). Female gender was associated with benign tumors only (OR = 6.43, 95% CI = 1.79–23.04, P = 0.004). No associations were observed between tumors and smoking (P = 0.24), alcohol consumption (P = 0.50), or body mass index (P = 0.21). Discussion: Our results confirm previous findings suggesting a limited role for common lifestyle factors and a potential genetic contribution in DM tumor predisposition. Muscle Nerve 57: 316–320, 2018.
Author(s): Alsaggaf R, Wang Y, Marini-Bettolo C, Wood L, Nikolenko N, Lochmuller H, Greene MH, Gadalla SM
Publication type: Article
Publication status: Published
Journal: Muscle and Nerve
Year: 2018
Volume: 57
Issue: 2
Pages: 316-320
Print publication date: 01/02/2018
Online publication date: 29/06/2017
Acceptance date: 24/06/2017
ISSN (print): 0148-639X
ISSN (electronic): 1097-4598
Publisher: John Wiley and Sons Inc.
URL: https://doi.org/10.1002/mus.25736
DOI: 10.1002/mus.25736
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