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Lookup NU author(s): Alaa Alyahya, Dr Sarah Charman, Dr Nduka OkwoseORCiD, Amy Fuller, Professor Christopher EggettORCiD, Peter Luke, Dr Guy MacGowanORCiD, Professor Djordje JakovljevicORCiD
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© 2023 Scandinavian Society of Clinical Physiology and Nuclear Medicine.Objectives: Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM. Methods: Twenty-eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m2) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m2) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded. Results: Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms2, p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml/beat/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m2, p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m2cm−5, p = 0.03). HF power was significantly related to SV (r = −0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM. Conclusions: Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.
Author(s): Alyahya AI, Charman SJ, Okwose NC, Fuller AS, Eggett C, Luke P, Bailey K, MacGowan GA, Jakovljevic DG
Publication type: Article
Publication status: Published
Journal: Clinical Physiology and Functional Imaging
Year: 2023
Volume: 43
Issue: 6
Pages: 421-430
Print publication date: 01/11/2023
Online publication date: 09/06/2023
Acceptance date: 07/06/2023
ISSN (print): 1475-0961
ISSN (electronic): 1475-097X
Publisher: John Wiley and Sons Inc
URL: https://doi.org/10.1111/cpf.12840
DOI: 10.1111/cpf.12840
PubMed id: 37293795
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