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Lookup NU author(s): Manuel Banzhaf
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2023 The Authors. Current design strategies for biomedical tissue scaffolds are focused on multifunctionality to provide beneficial microenvironments to support tissue growth. We have developed a simple yet effective approach to create core–shell fibers of poly(3-hydroxybuty-rate-co-3-hydroxyvalerate) (PHBV), which are homogenously covered with titanium dioxide (TiO2) nanoparticles. Unlike the blend process, co-axial electrospinning enabled the uniform distribution of nanoparticles without the formation of large aggregates. We observed 5 orders of magnitude reduction in Escherichia coli survival after contact with electrospun scaffolds compared to the non-material control. In addition, our hybrid cores-shell structure supported significantly higher osteoblast proliferation after 7 days of cell culture and profound generation of 3D networked collagen fibers after 14 days. The organic–inorganic composite scaffold produced in this study demonstrates a unique combination of antibacterial properties and increased bone regeneration properties. In summary, the multifunctionality of the presented core–shell cPHBV+sTiO2 scaffolds shows great promise for biomedical applications.
Author(s): Karbowniczek JE, Berniak K, Knapczyk-Korczak J, Williams G, Bryant JA, Nikoi ND, Banzhaf M, de Cogan F, Stachewicz U
Publication type: Article
Publication status: Published
Journal: Journal of Colloid and Interface Science
Year: 2023
Volume: 650
Pages: 1371-1381
Print publication date: 15/11/2023
Online publication date: 12/07/2023
Acceptance date: 11/07/2023
Date deposited: 09/08/2023
ISSN (print): 0021-9797
ISSN (electronic): 1095-7103
Publisher: Academic Press Inc.
URL: https://doi.org/10.1016/j.jcis.2023.07.066
DOI: 10.1016/j.jcis.2023.07.066
PubMed id: 37480652
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