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Lookup NU author(s): Professor Djordje JakovljevicORCiD
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
This review emphasizes the importance of cardiopulmonary exercise testing (CPET) in patients diagnosed with hypertrophic cardiomyopathy (HCM). In contrast to standard exercise testing and stress echoes, which are limited due to the ECG changes and wall motion abnormalities that characterize this condition, CPET allows for the assessment of the complex pathophysiology and severity of the disease, its mechanisms of functional limitation, and its risk stratification. It is useful tool to evaluate the risk for sudden cardiac death and select patients for cardiac resynchronization therapy (CRT), cardiac transplantation, or mechanical circulatory support, especially when symptomatology and functional status are uncertain. It may help in differentiating HCM from other forms of cardiac hypertrophy, such as athletes' heart. Finally, it is used to guide and monitor therapy as well as for exercise prescription. It may be considered every 2 years in clinically stable patients or every year in patients with worsening symptoms. Although performed only in specialized centers, CPET combined with echocardiography (i.e., CPET imaging) and invasive CPET are more informative and provide a better assessment of cardiac functional status, left ventricular outflow tract obstruction, and diastolic dysfunction during exercise in patients with HCM.
Author(s): Mikic L, Ristic A, Markovic Nikolic N, Tesic M, Jakovljevic DG, Arena R, Allison TG, Popovic D
Publication type: Review
Publication status: Published
Journal: Medicina
Year: 2023
Volume: 59
Issue: 7
Online publication date: 13/07/2023
Acceptance date: 10/07/2023
ISSN (electronic): 1648-9144
Publisher: MDPI
URL: https://doi.org/10.3390/medicina59071296
DOI: 10.3390/medicina59071296
PubMed id: 37512108
