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Docking domains and substrate-specificity determination for MAP kinases

Lookup NU author(s): Alexios Galanis

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Abstract

Signalling specificity in eukaryotic cells is maintained by several mechanisms. One mechanism by which mitogen-activated protein (MAP) kinases ensure their specificity of action is by interacting with their substrates through docking domains. These docking domains recruit the kinases to the correct substrates and enhance their fidelity and efficiency of action. Additional specificity determinants in the substrates serve to enhance the specificity of substrate phosphorylation by MAP kinases further. Copyright (C) 2000 Elsevier Science Ltd.

Publication metadata

Author(s): Sharrocks AD, Yang S-H, Galanis A

Publication type: Review

Publication status: Published

Journal: Trends in Biochemical Sciences

Year: 2000

Volume: 25

Issue: 9

Pages: 448-453

ISSN (print): 0968-0004

ISSN (electronic): 0167-7640

URL: http://dx.doi.org/10.1016/S0968-0004(00)01627-3

DOI: 10.1016/S0968-0004(00)01627-3

PubMed id: 10973059

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