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Sox9 induces testis development in XX transgenic mice

Lookup NU author(s): Dr Valerie Vidal, Marie-Christine Chaboissier, Professor Andreas Schedl

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Abstract

Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads. Here, we show that Sox9 is sufficient to induce testis formation in mice, indicating that it can substitute for the sex-determining gene Sry.

Publication metadata

Author(s): Vidal VPI, Chaboissier M-C, De Rooij DG, Schedl A

Publication type: Article

Publication status: Published

Journal: Nature Genetics

Year: 2001

Volume: 28

Issue: 3

Pages: 216-217

Print publication date: 01/01/2001

ISSN (print): 1061-4036

ISSN (electronic): 1469-7750

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1038/90046

DOI: 10.1038/90046

PubMed id: 11431689

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