Browse by author
Lookup NU author(s): Dr Jayne Lamont, Professor Deborah Tweddle, Professor Andrew Pearson, Professor Steven CliffordORCiD, Professor David Ellison
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
A boy aged 7 years was found to have a tumor arising from the roof of the fourth ventricle. Histopathologically, part of the tumor appeared as a PNET, while neuroglial tissue, striated and smooth muscle, cartilage and small glandular structures were present in other regions. Tumor cells in both primitive and mature elements showed a loss of chromosome 17p accompanied by a gain of 17q, a pattern consistent with the presence of an isochromosome 17q. This abnormality is not characteristic of intracranial germ cell tumors, but is present in over 30% of medulloblastomas. On the basis of the histologic and genetic abnormalities, we propose a diagnosis of PNET with multilineal differentiation.
Author(s): Ismail A, Lamont JM, Tweddle DA, Pearson ADJ, Clifford SC, Ellison DW
Publication type: Article
Publication status: Published
Journal: Brain Pathology
Year: 2005
Volume: 15
Issue: 3
Pages: 261-261
Print publication date: 01/07/2005
ISSN (print): 1015-6305
ISSN (electronic): 1750-3639
PubMed id: 16196393
