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Lookup NU author(s): Dr Jonathan Smout, Professor Gerard Stansby
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Objectives: Platelet monocyte aggregates (PMA) and monocyte chemoattractant protein-1 (MCP-1) play a significant role in atherosclerotic disease but the effect of aspirin and their role in peripheral arterial disease (PAD) requires further investigation. We have compared p-selectin, PMA and MCP-1 in patients with PAD treated with aspirin (75mgs daily), with age matched controls not treated with aspirin. Materials and methods: Using flow cytometry and ELISA, P-selectin, PMA and MCP-1 were compared in 3 populations; healthy controls (n = 12), intermittent claudication (n = 19) and critical limb ischaemia (CLI), (n = 10). Results: P-selectin was significantly higher in CLI patients (3.48% positive) compared to the claudicants (1. 36% positive) and the controls (1.76% positive). PMA levels were significantly higher for CLI population (44.5% positive) compared to the claudicants (20.48% positive) and the controls (28.33% positive). MCP-1 levels expression was significantly higher for the CLI patients (175.4 pg/mL) compared to the claudicants (76.1 pg/mL) and the controls (117.0 pg/mL). Conclusion: Despite aspirin treatment CLI patients have higher platelet activation and MCP-1 expression than controls and claudicants. With increasing severity of disease aspirin is unable to suppress markers of platelet activation and pro-atherosclerotic chemokine expression which may represent another form of aspirin resistance. © 2007 Elsevier Ltd. All rights reserved.
Author(s): Cleanthis M, Bhattacharya V, Smout J, Ashour H, Stansby G
Publication type: Article
Publication status: Published
Journal: European Journal of Vascular and Endovascular Surgery
Year: 2007
Volume: 33
Issue: 6
Pages: 725-730
ISSN (print): 1078-5884
ISSN (electronic): 1532-2165
Publisher: Elsevier Ltd
URL: http://dx.doi.org/10.1016/j.ejvs.2006.12.025
DOI: 10.1016/j.ejvs.2006.12.025
PubMed id: 17296320
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