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Outcome of a risk-related therapeutic strategy used prospectively in a population-based study of Hodgkin's lymphoma in adolescents

Lookup NU author(s): Dr Penelope Taylor, Dr Kevin Windebank, Dr Helen Lucraft, Dr Katrina Wood, Dr Brian Angus, Professor Stephen Proctor

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Abstract

The aim was to assess outcome in a population-based cohort of adolescents with Hodgkin's lymphoma (HL) diagnosed in the UK's northern region over a 10-year period. Among a population of 3.09 million, 55 of 676 patients (8%) diagnosed with HL were aged 13-19. Seven had nodular lymphocyte-predominant HL, 48 classical HL (cHL). Of the latter, 36 were ≥16 years. Application of the Scottish and Newcastle Lymphoma Group (SNLG) prognostic index meant 21 patients were considered high risk (index ≥0.5). They received PVACEBOP multi-agent chemotherapy as primary therapy. Standard risk patients (SNLG index <0.5) were treated with standard ChlVPP or ABVD chemotherapy±radiotherapy. Scottish and Newcastle Lymphoma Group indexing is not valid for patients under 16. Twelve patients therefore received UKCCSG protocols (n=8), ABVD plus radiotherapy (n=2), or PVACEBOP (n=2). Forty-six patients with cHL (96%) achieved complete remission. Seven patients relapsed but all entered complete remission after salvage therapy. Five patients died: three of HL, one in an accident and one of disseminated varicella complicating cystic fibrosis. Five- and 10-year overall survival was 93 and 86%, respectively; disease-specific survival was 95 and 92%. The data suggest that older adolescents with high-risk HL require intensive protocols as primary therapy to secure optimal outcome. © 2007 Cancer Research UK.

Publication metadata

Author(s): Jones GL, Taylor PRA, Windebank KP, Hoye NA, Lucraft HH, Wood K, Angus B, Proctor SJ

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 2007

Volume: 97

Issue: 1

Pages: 29-36

Print publication date: 26/06/2007

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

URL: http://dx.doi.org/10.1038/sj.bjc.6603809

DOI: 10.1038/sj.bjc.6603809

PubMed id: 17533403

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