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Browsing publications by Duncan Miller.

Newcastle AuthorsTitleYearFull text
Dr Elaine Willmore
Suzanne Kyle
Dr Yan Zhao
Huw Thomas
Dr Kenneth Rankin
et al.
Targeting the MDM2-p53 interaction: Time- and concentration-dependent studies in tumor and normal human bone marrow cells reveal strategies for an enhanced therapeutic index2024
Duncan Miller
Dr Suzannah Harnor
Dr Mathew Martin
Dr Richard Noble
Professor Steve Wedge
et al.
Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy2023
Duncan Miller
Tristan Reuillon
Dr Lauren Molyneux
Dr Tim Blackburn
Dr Noel Edwards
et al.
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor2022
Islam Al-Khawaldeh
Dr Christine Basmadjian
Dr Cinzia Bordoni
Dr Suzannah Harnor
Amy Heptinstall
et al.
An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)2021
Dr Cinzia Bordoni
Daniel Brough
Gemma Davison
James Hunter
Daniel Lopez Fernandez
et al.
Cardiac Ion Channel Inhibition2021
Dr Ian Hardcastle
Dr Ruth Bawn
Dr Tim Blackburn
Dr Celine Cano
Dr Sarah Cully
et al.
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction2021
Daniel Wood
Daniel Lopez Fernandez
Leanne Knight
Islam Al-Khawaldeh
Dr Conghao Gai
et al.
FragLites - minimal, halogenated fragments displaying pharmacophore doublets. An efficient approach to druggability assessment and hit generation2019
Stephanie Myers
Duncan Miller
Dr Lauren Molyneux
Dr Mercedeh Arasta
Dr Ruth Bawn
et al.
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD42019
Duncan Miller
The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain2019
Duncan Miller
Dr Mathew Martin
Santosh Adhikari
Alfie Brennan
Professor Jane Endicott
et al.
Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach2018
Professor David Rees
Emeritus Professor Bernard Golding
Dr Ian Hardcastle
Dr Celine Cano
Duncan Miller
et al.
ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY2017
Professor David Rees
Emeritus Professor Bernard Golding
Dr Ian Hardcastle
Dr Celine Cano
Duncan Miller
et al.
Preparation of isoindolinones as inhibitors of the MDM2-​p53 interaction having anticancer activity2017
Professor David Rees
Emeritus Professor Bernard Golding
Dr Ian Hardcastle
Dr Celine Cano
Duncan Miller
et al.
Preparation of isoindolinones as inhibitors of the MDM2-​p53 interaction having anticancer activity;WO 20170558602017
Tristan Reuillon
Dr Sari Alhasan
Dr Gary Beale
Annalisa Bertoli
Alfie Brennan
et al.
Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases2016
Duncan Miller
Discovery and optimisation of potent and highly subtype selective Nav1.8 inhibitors with reduced cardiovascular liabilities2016
Tristan Reuillon
Duncan Miller
Stephanie Myers
Dr Lauren Molyneux
Dr Celine Cano
et al.
Pyrrolcarboxamide Derivatives for the Inhibition of ERK52016
Professor Mike Waring
Duncan Miller
Challenges in the Medicinal Chemical Optimization of Binding Kinetics2015
Duncan Miller
Dr Benoit Carbain
Dr Gary Beale
Dr Sari Alhasan
Professor Helen Reeves
et al.
Regioselective sulfamoylation at low temperature enables concise syntheses of putative small molecule inhibitors of sulfatases2015
Andrew Shouksmith
Laura Evans
Professor Deborah Tweddle
Duncan Miller
Dr Elaine Willmore
et al.
Synthesis and Activity of Putative Small-​Molecule Inhibitors of the F-​Box Protein SKP22015
Andrew Shouksmith
Laura Evans
Professor Roger Griffin
Emeritus Professor Bernard Golding
Professor Herbie Newell
et al.
Design and synthesis of putative small-molecule inhibitors targeting the SCFSKP2 E3 ligase complex2014
Duncan Miller
Benzimidazole and imidazopyridine derivatives as Nav1.8 inhibitors and their preparation and use in the treatment of pain2013
Duncan Miller
Imidazoles as Nav1.8 inhibitors and their preparation and use in the treatment of pain2013
Tristan Reuillon
Annalisa Bertoli
Professor Roger Griffin
Duncan Miller
Emeritus Professor Bernard Golding
et al.
Efficacious N-protection of O-aryl sulfamates with 2,4-dimethoxybenzyl groups2012
Duncan Miller
Dr Peter Jones
Investigation of the effect of molecular properties on the binding kinetics of a ligand to its biological target2012