Publications by Professor Matthias Trost - ePrints

Browsing publications by Professor Matthias Trost.

Newcastle Authors	Title	Year
Professor Matthias Trost Dr Maria Duenas Fadic	A high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of the antigen aminopeptidase ERAP1	2023
Alba Méndez Alejandre Dr Ben Raymond Professor Matthias Trost Dr Jose Luis Marin-Rubio	Bi-functional particles for real-time phagosome acidification and proteolysis multiplex assay in macrophages	2023
Dr Javier Abellon-Ruiz Dr Augustinas Silale Dr Andrew Frey Dr Arnaud Basle Professor Matthias Trost et al.	BtuB TonB-dependent transporters and BtuG surface lipoproteins form stable complexes for vitamin B₁₂ uptake in gut Bacteroides	2023
Amy George Frances Sidgwick Dr Jessica Watt Dr Mathew Martin Professor Matthias Trost et al.	Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling	2023
Omar Al-Jourani Dr Jenn Ross Dr Nick Bailey Dr Tiaan Heunis Joseph Manion et al.	Identification of D-arabinan-degrading enzymes in mycobacteria	2023
Dr Augustinas Silale Matthew Feasey Dr Tiaan Heunis Dr Yiling Zhu Dr Hong Zheng et al.	Outer membrane utilisomes mediate glycan uptake in gut Bacteroidetes	2023
Professor Matthias Trost	Reversal of cell, circuit and seizure phenotypes in a mouse model of DNM1 epileptic encephalopathy	2023
Dr Jose Luis Marin-Rubio Jack Gudgeon Frances Sidgwick Professor Matthias Trost	A Dual Role for FADD in Human Precursor T-Cell Neoplasms	2022
Dr Jose Luis Marin-Rubio Dr Maria Duenas Fadic Dr Tiaan Heunis Dr Abeer Dannoura Dr Joe Inns et al.	A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia	2022
Dr Tiaan Heunis Professor Matthias Trost	Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism	2022
Dr Olivier Govaere Dr Rebecca Darlay Dr Julien Peltier Dr Jeremy Palmer Dr Massimo Younes et al.	Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease	2022
Dr Maria Duenas Fadic Professor Matthias Trost	MALDI-TOF mass spectrometry in the 21st century	2022
Dr Tiaan Heunis Dr Jose Luis Marin-Rubio Francesca Cianfanelli Dr Ben Raymond Dr Joe Inns et al.	The E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to bacterial infection	2022
Jack Gudgeon Dr Jose Luis Marin-Rubio Professor Matthias Trost	The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer	2022
Dr Marzena Kurzawa-Akanbi Rachel Heap Professor Matthias Trost Dr Preeti Singh Dr Florence Burte et al.	Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders	2021
Dr Akshada Gajbhiye Professor Matthias Trost	Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes	2021
Catherine Hatton Dr Rachel Botting Dr Maria Duenas Fadic Dr Iram Haq Dr Bernard Verdon et al.	Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2	2021
Rachel Heap Dr Jose Luis Marin-Rubio Dr Julien Peltier Dr Tiaan Heunis Dr Abeer Dannoura et al.	Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation	2021
Dr Julien Peltier Dr Tiaan Heunis Professor Matthias Trost	TPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria	2021
Dr Fatima Ulhuq Dr Chriselle Mendonca Dr Grant Buchanan Dr Henrik Strahl von Schulten Professor Matthias Trost et al.	A membrane-depolarizing toxin substrate of the Staphylococcus aureus Type VII secretion system mediates intra-species competition	2020
Dr Jack Leslie Dr Marina Garcia Macia Dr Saimir Luli Dr Julie Worrell William Reilly et al.	c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis	2020
Professor Matthias Trost	High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry–based deubiquitylating enzyme assay for drug discovery	2020
Dr Tiaan Heunis Professor Matthias Trost	Investigating Non-sterilizing Cure in TB Patients at the End of Successful Anti-TB Therapy	2020
Dr Tiaan Heunis Dr Frederic Lamoliatte Dr Jose Luis Marin-Rubio Dr Abeer Dannoura Professor Matthias Trost et al.	Technical report: Targeted proteomic analysis reveals enrichment of atypical ubiquitin chains in contractile murine tissues	2020
Dr Akshada Gajbhiye Professor Matthias Trost	USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation	2020
Dr Alan Cartmell Dr Jose Munoz Munoz Dr Jonathan Briggs Dr Didier Ndeh Dr Elisabeth Lowe et al.	Author Correction: A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation	2019
Professor Matthias Trost	Macrophage phosphoproteome analysis reveals MINCLE-dependent and-independent mycobacterial cord factor signaling	2019
Nazma Malik Dr Julien Peltier Robert Gourlay Professor Matthias Trost	Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44	2019
Rachel Heap Dr Alasdair Blain Professor Matthias Trost	Profiling embryonic stem cell differentiation by MALDI TOF mass spectrometry: Development of a reproducible and robust sample preparation workflow	2019
Dr Paul Dean Dr Tiaan Heunis Professor Matthias Trost	Regulation of phagosome functions by post-translational modifications: a new paradigm	2019
Dr Julien Peltier Professor Matthias Trost	Spatiotemporal Changes of the Phagosomal Proteome in Dendritic Cells in Response to LPS Stimulation	2019
Professor Matthias Trost	Triggering MSR1 promotes JNK-mediated inflammation in IL-4-activated macrophages	2019
Professor Matthias Trost	Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death	2019
Dr Alan Cartmell Dr Jose Munoz Munoz Dr Jonathan Briggs Dr Didier Ndeh Dr Elisabeth Lowe et al.	A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status forarabinogalactan degradation	2018
Dr Julien Peltier Professor Matthias Trost	Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11	2018
Professor Matthias Trost	Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells	2018
Dr Giusy Mariano Dr Julien Peltier Professor Matthias Trost	Killing with proficiency: Integrated post-translational regulation of an offensive Type VI secretion system	2018
Dr Julien Peltier Professor Matthias Trost	LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages	2018
Dr Julien Peltier Professor Matthias Trost	Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase	2018
Professor Matthias Trost	The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway	2018
Dr Katharina Trunk Dr Julien Peltier Professor Janet Quinn Dr Henrik Strahl von Schulten Professor Matthias Trost et al.	The type VI secretion system deploys antifungal effectors against microbial competitors	2018
Dr Julien Peltier Professor Matthias Trost	Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib	2018
Robert Gourlay Professor Matthias Trost	A mutant O-GlcNAcase enriches Drosophila developmental regulators	2017
Dr Julien Peltier Dr Anetta Svitorka Hartlova Professor Matthias Trost	Assessing the Phagosome Proteome by Quantitative Mass Spectrometry	2017
Rachel Heap Professor Matthias Trost	Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)	2017
Dr Anetta Svitorka Hartlova Dr Julien Peltier Professor Matthias Trost	Isolation and Western Blotting of Latex-Bead Phagosomes to Track Phagosome Maturation	2017
Professor Matthias Trost	Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G₀/G₁ Arrest by Inhibiting Deubiquitinase USP2a	2017
Rachel Heap Megan Gant Frederic Lamoliatte Dr Julien Peltier Professor Matthias Trost et al.	Mass spectrometry techniques for studying the ubiquitin system	2017
Professor Matthias Trost	Patterns, Receptors, and Signals: Regulation of Phagosome Maturation	2017
Professor Matthias Trost	USP7 small-molecule inhibitors interfere with ubiquitin binding	2017
Professor Matthias Trost	Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation	2016
Professor Matthias Trost	IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid	2016
Professor Matthias Trost	mTORC1 and CK2 coordinate ternary and eIF4F complex assembly	2016
Professor Matthias Trost	Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases	2016
Dr Julien Peltier Professor Matthias Trost	Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity	2016
Dr Alexandra Solovyova Professor Matthias Trost	UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome	2016
Professor Matthias Trost	VgrG and PAAR proteins define distinct versions of a functional Type VI secretion system	2016
Dr Julien Peltier Professor Matthias Trost	Binding to serine 65‐phosphorylated ubiquitin primes Parkin for optimal PINK1‐dependent phosphorylation and activation	2015
Professor Matthias Trost	High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow-derived macrophages	2015
Robert Gourlay Professor Matthias Trost	Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1	2015
Professor Matthias Trost	Quantitative proteome analysis of temporally-resolved phagosomes following uptake via key phagocytic receptors	2015
Professor Matthias Trost	Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers	2015
Professor Matthias Trost	A crucial role for β2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells	2014
Professor Matthias Trost Professor Tracy Palmer FRS FRSE FMedSci Professor Frank Sargent	A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens	2014
Robert Gourlay Professor Matthias Trost	Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Serine⁶⁵	2014
Professor Matthias Trost	Protein kinase D2 is a digital amplifier of T cell receptor–stimulated diacylglycerol signaling in naïve CD8+ T cells	2014
Professor Matthias Trost	Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO₂and Ti-IMAC	2014
Professor Matthias Trost	Screening of DUB activity and specificity by MALDI-TOF mass spectrometry	2014
Professor Matthias Trost	A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870	2013