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Browsing publications by Julian Leathart.

Newcastle AuthorsTitleYearFull text
Dr Yang-Lin Liu
Dr Gillian Patman
Julian Leathart
Professor Alastair Burt
Professor Chris Day
et al.
Carriage of the PNPLA3 rs738409 C>G Polymorphism Confers an Increased Risk of Non-Alcoholic Fatty Liver Disease Associated Hepatocellular Carcinoma2014
Julian Leathart
Professor Ann Daly
Professor Chris Day
Professor Quentin Anstee
Gene Polymorphisms of Cellular Senescence Marker P21 and Disease Progression in Non-Alcohol-Related Fatty Liver Disease2014
Dr Yang-Lin Liu
Professor Helen Reeves
Professor Alastair Burt
Dr Dina Tiniakos
Professor Stuart McPherson
et al.
TM6SF2 rs58542926 Influences Hepatic Fibrosis Progression in Patients with Non-Alcoholic Fatty Liver Disease2014
Professor Quentin Anstee
Dr Rebecca Darlay
Julian Leathart
Yilei Liu
Professor Alastair Burt
et al.
A candidate-gene approach to validation of genetic modifier associations using a large cohort with histologically characterised non-alcoholic fatty liver disease2013
Dr Patrick Kesteven
Julian Leathart
Professor Ann Daly
Professor Farhad Kamali
A Randomized Trial of Genotype-Guided Dosing of Warfarin2013
Dr Yang-Lin LIU
Dr Gillian Patman
Julian Leathart
Professor Alastair Burt
Professor Chris Day
et al.
Carriage of PNPLA3 I148M is Associated with an Increased Risk of Non-Alcoholic Fatty Liver Disease Associated Hepatocellular Carcinoma2013
Professor Quentin Anstee
Dr Rebecca Darlay
Julian Leathart
Professor Helen Reeves
Professor Alastair Burt
et al.
Genome-Wide Association Analysis Confirms Importance of PNPLA3 and Identifies Novel Variants Associated With Histologically Progressive Steatohepatitis in NAFLD2012
Ahmad Alserri
Professor Quentin Anstee
Julian Leathart
Julia Patch
Professor Chris Day
et al.
The SOD2 C47T polymorphism influences NAFLD fibrosis severity: Evidence from case-control and intra-familial allele association studies2012
Dr Tina Biss
Dr Peter Avery
Julian Leathart
Professor Farhad Kamali
VKORC1 and CYP2C9 genotype is associated with over-anticoagulation during initiation of warfarin therapy in children2012
Dr Tina Biss
Dr Peter Avery
Julian Leathart
Professor Farhad Kamali
Warfarin dose prediction in children using pharmacogenetics information2012
Dr Tina Biss
Dr Peter Avery
Julian Leathart
Dr John Hanley
Professor Ann Daly
et al.
VKORC1 and CYP2C9 genotype and patient characteristics explain a large proportion of the variability in warfarin dose requirement among children2011
Dr Gul Ozhan
Rajiv Lochan Jayadeva
Julian Leathart
Richard Charnley
Professor Ann Daly
et al.
Cyclooxygenase-2 polymorphisms and pancreatic cancer susceptibility2011
Julian Leathart
Professor Ann Daly
Genotyping for CYP2C9 and VKORC1 alleles by a novel point of care assay with HyBeacon(R) probes2011
Dr Nimantha De Alwis
Julian Leathart
Professor Gavin Hudson
Dr Angela Pyle
Dr Catherine Mowbray
et al.
Mitochondrial DNA does not contribute to the heritability of non-alcoholic fatty liver disease2011
Julian Leathart
Professor Ann Daly
Professor Chris Day
The APOC3 T-455C and C-482T promoter region polymorphisms are not associated with the severity of liver damage independently of PNPLA3 I148M genotype in patients with nonalcoholic fatty liver2011
Professor Ann Daly
Julian Leathart
Professor Alastair Burt
Professor Chris Day
Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease2010
Dr Stuart Kendrick
Julian Leathart
Elsbeth Henderson
Dr Nimantha De Alwis
Dr Stephen Stewart
et al.
A 'loss-of-function' mutation in TIRAP, the gene encoding the Toll-like receptor adapter molecule MAL protects against fibrosis in NAFLD but not ALD2008
Dr Peter Donaldson
Dr Pallav Bhatnagar
Julia Patch
Jill Henderson
Julian Leathart
et al.
Flucloxacillin-induced liver injury: the extended MHC 57.1 haplotype as a major risk factor2008
Dr Peter Donaldson
Dr Pallav Bhatnagar
Julia Patch
Jill Henderson
Julian Leathart
et al.
Susceptibility to drug induced liver injury determined by HLA class II genotype2008
Dr Luca Miele
Dr Gary Beale
Dr Gillian Patman
Julian Leathart
Professor Chris Day
et al.
The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease2008
Dr Nimantha De Alwis
Professor Ann Daly
Julian Leathart
Dr Sushma Saksena
Professor Chris Day
et al.
Genetic evidence that lipid trafficking plays a key role in fibrosis in non alcoholic fatty liver disease2007
Professor Ann Daly
Julian Leathart
Richard Swainsbury
Professor Chris Day
Genetic Susceptibility to Diclofenac-Induced Hepatotoxicity: Contribution of UGT2B7, CYP2C8, and ABCC2 Genotypes2007
Dr Nimantha De Alwis
Dr Catherine Mowbray
Dr Angela Pyle
Julian Leathart
Professor Patrick Chinnery
et al.
Mitochondrial DNA haplogroups associated with histological severity in non-alcoholic fatty liver disease (NAFLD)2007
Dr Luca Miele
Dr Gary Beale
Julian Leathart
Professor Chris Day
Professor Helen Reeves
et al.
The KLF6 (IVS1-27G > a) polymorphism is associated with non-progressive NAFLD2007
Professor Ann Daly
Ahmad Alserri
Julian Leathart
Julia Patch
Professor Chris Day
et al.
The mitochondrial superoxide dismutase 2 (SOD2) targeting sequence polymorphism is associated with fibrotic NAFLD: Consistent evidence from case-control and intra-familial allelic association studies2007
Professor Chris Day
Julian Leathart
Professor Ann Daly
Genetic evidence for a role for gut flora in the pathogenesis of NASH in humans2006
Professor Ann Daly
Dr Barry King
Julian Leathart
Genotyping for cytochrome P450 polymorphisms2006
Dr David Price
Dr Peter Donaldson
Julian Leathart
Professor Alastair Burt
Dr Matthias Schmid
et al.
Microsomal triglyceride transfer protein gene promoter polymorphism (493g allele) is associated with severity of hcv-associated steatosis2006
Julian Leathart
Professor Ann Daly
Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics2005
Vanessa Gage
Professor Peter Blain
Julian Leathart
Professor Ann Daly
Professor Faith Williams
et al.
Association of DNA damage to human peripheral lymphocytes with age and MnSOD and OGG1 genotype2004
Professor Ann Daly
Julian Leathart
Professor Chris Day
Hepatic Adducts, Circulating Antibodies, and Cytokine Polymorphisms in Patients with Diclofenac Hepatotoxicity2004
Professor Ann Daly
Julian Leathart
Professor Chris Day
A "loss-of-function" polymorphism in ICAM-1 protects heavy drinkers from alcoholic liver disease2003
Dr Barry King
Julian Leathart
Dr Elaine Mutch
Professor Faith Williams
Professor Ann Daly
et al.
CYP3A5 phenotype-genotype correlations in a British population2003
Dr Elaine Mutch
Professor Ann Daly
Julian Leathart
Professor Peter Blain
Professor Faith Williams
et al.
Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?2003
Professor Ann Daly
Julian Leathart
Dr Beate Haugk
Professor David Jones
Professor Alastair Burt
et al.
Evidence that alcoholic liver disease is due to immune mechanisms in genetically susceptible drinkers2003
Dr Stephen Stewart
Professor Ann Daly
Professor David Jones
Julian Leathart
Professor Chris Day
et al.
Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease2003
Dr Sushma Saksena
Julian Leathart
Professor Alastair Burt
Emeritus Professor Oliver James
Professor Ann Daly
et al.
Genetic evidence supporting the two-hit model of NASH pathogenesis2003
Dr Sushma Saksena
Julian Leathart
Professor Ann Daly
Professor Chris Day
Manganese dependent superoxide dismutase (SOD2) targeting sequence polymorphism is associated with advanced fibrosis in patients with non-alcoholic fatty liver disease2003
Julian Leathart
Professor Ann Daly
Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide2003
Julian Leathart
Professor Chris Day
Professor Ann Daly
Relationship of UGT2B7 genotype with diclofenac hepatotoxicity2003
Julian Leathart
Professor Chris Day
Professor Ann Daly
Association of udp-glucuronosyltransferase (UGT) 2B7 genotype with diclofenac-induced hepatotoxicity2002
Dr Namrata Bahadur
Julian Leathart
Dr Elaine Mutch
Dr Stuart Dunn
Professor Faith Williams
et al.
CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes2002
Professor Ann Daly
Julian Leathart
Dr Beate Haugk
Professor David Jones
Professor Alastair Burt
et al.
Evidence that alcoholic liver disease is due to immune mechanisms in genetically susceptible drinkers2002
Professor Chris Day
Dr Sushma Saksena
Julian Leathart
Professor Alastair Burt
Emeritus Professor Oliver James
et al.
Genetic evidence supporting the two-hit model of NASH pathogenesis2002
Professor Chris Day
Julian Leathart
Professor Ann Daly
Genetic evidence that fatty liver is involved in the pathogenesis of advanced alcoholic liver disease2002
Dr Stephen Stewart
Julian Leathart
Professor Ann Daly
Professor Chris Day
Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis2002
Dr Stephen Stewart
Professor Ann Daly
Julian Leathart
Professor David Jones
Professor Chris Day
et al.
A polymorphism in CTLA-4 is associated with the presence of anti-CYP2E1 antibody titres in patients with alcoholic liver disease2001
Julian Leathart
Sally Keegan
Jeffrey Pearson
Dr Adrian Bint
Analysis of Escherichia coli strains causing bacteriuria during pregnancy2001
Julian Leathart
Sally Keegan
Dr Adrian Bint
Analysis of Escherichia coli strains causing bacteriuria during pregnancy: Selection for strains that do not express type 1 fimbriae2001
Professor Chris Day
Julian Leathart
Professor Ann Daly
Dr Mark Hudson
Association of a 5'-flanking region polymorphism in the interleukin-4 gene with Crohn’s disease in a British population.2001
Professor Chris Day
Julian Leathart
Professor Ann Daly
Dr Mark Hudson
Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population2001
Dr Kaushik Agarwal
Professor Ann Daly
Julian Leathart
Dr Mark Hudson
Professor Chris Day
et al.
Polymorphisms of immunoregulatory genes: A step towards individually tailored immunosuppression?2001
Professor Chris Day
Julian Leathart
Professor Ann Daly
Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis2000
Professor Alan Boddy
Emerita Professor Suzanne Cholerton
Professor Ann Daly
Professor Janice Ellis
Julian Leathart
et al.
The pharmacogenetics of chemical carcinogenesis1992