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Browsing publications by Dr Paul Smith.

Newcastle AuthorsTitleYearFull text
Dr Joanna Elson
Dr Paul Smith
Heterologous Inferential Analysis (HIA) as a Method to Understand the Role of Mitochondrial rRNA Mutations in Pathogenesis2015
Dr Joanna Elson
Dr Paul Smith
Dr Laura Greaves
Professor Robert Lightowlers
Professor Zofia Chrzanowska-Lightowlers
et al.
The presence of highly disruptive 16S rRNA mutations in clinical samples indicates a wider role for mutations of the mitochondrial ribosome in human disease2015
Dr Veronika Boczonadi
Dr Paul Smith
Dr Angela Pyle
Dr Aurora Gomez Duran
Professor Patrick Chinnery
et al.
Altered 2-thiouridylation impairs mitochondrial translation in reversible infantile respiratory chain deficiency2013
Dr Veronika Boczonadi
Dr Paul Smith
Professor Patrick Chinnery
Professor Rita Horvath
Defective thiolation impairs mitochondrial translation offering a therapy approach in reversible infantile respiratory chain deficiency2013
Dr Paul Smith
Dr Joanna Elson
Dr Laura Greaves
Professor Robert Lightowlers
Professor Zofia Chrzanowska-Lightowlers
et al.
The role of the mitochondrial ribosome in human disease: Searching for mutations in 12S mitochondrial rRNA with high disruptive potential2013
Dr Veronika Boczonadi
Dr Paul Smith
Kamil Sitarz
Professor Zofia Chrzanowska-Lightowlers
Professor Robert Lightowlers
et al.
Studying the molecular basis of the reversibility in infantile reversible cytochrome c oxidase deficiency2012
Dr Paul Smith
Professor Robert Lightowlers
Altering the balance between healthy and mutated mitochondrial DNA2011
Ricarda Richter
Dr Joanna Rorbach
Aleksandra Pajak
Dr Paul Smith
Professor Robert Lightowlers
et al.
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome2010
Professor Rita Horvath
Dr Helen Tuppen
Professor Gavin Hudson
Dr Angela Pyle
Dr Paul Smith
et al.
Infantile reversible COX deficiency myopathy caused by the m.14674T > C mutation in mt-tRNA(Glu) in a German family2010
Sven Dennerlein
Dr Paul Smith
Dr Agata Rozanska
Professor Robert Lightowlers
Professor Zofia Chrzanowska-Lightowlers
et al.
Knowing when to stop - human mitochondrial translation termination2010
Professor Rita Horvath
Dr Helen Tuppen
Professor Gavin Hudson
Dr Angela Pyle
Dr Paul Smith
et al.
Molecular basis of infantile reversible cytochrome c oxidase deficiency myopathy2009
Professor Zofia Chrzanowska-Lightowlers
Dr Richard Temperley
Dr Paul Smith
Professor Robert Lightowlers
Functional polypeptides can be synthesized from human mitochondrial transcripts lacking termination codons2004
Dr Paul Smith
Dr Gunther Ross
Professor Robert Taylor
Emeritus Professor Doug Turnbull
Professor Robert Lightowlers
et al.
Bridging PNAs can bind preferentially to a deleted mitochondrial DNA template but replication by mitochondrial DNA polymerase γ in vitro is not impaired2003
Professor Robert Lightowlers
Dr Paul Smith
Specific targeting of a DNA-alkylating reagent to mitochondria: Synthesis and characterization of [4-((11aS)-7-methoxy-1,2,3,11a-tetrahydro-5H-pyrrolo[2,1-c][1,4] benzodiazepin-5-on-8-oxy)butyl]-triphenylphosphonium iodide2003
Dr Gunther Ross
Dr Paul Smith
Emeritus Professor Doug Turnbull
Professor Robert Lightowlers
Synthesis of trifunctional PNA-benzophenone derivatives for mitochondrial targeting, selective DNA binding, and photo-cross-linking2003
Dr Paul Smith
Dr Gunther Ross
Dr Theresa Wardell
Professor Robert Taylor
Emeritus Professor Doug Turnbull
et al.
The use of PNAs and their derivatives in mitochondrial gene therapy2003
Professor Robert Taylor
Dr Theresa Wardell
Dr Paul Smith
Emeritus Professor Doug Turnbull
Professor Robert Lightowlers
et al.
An antigenomic strategy for treating heteroplasmic mtDNA disorders2001
Linda Smith
Dr Paul Smith
Behavioural treatment of urinary incontinence and encopresis in children with learning disabilities: transfer of stimulus control2000