Toggle Main Menu Toggle Search

Open Access padlockePrints

Browsing publications by Emeritus Professor Harry Gilbert.

Newcastle AuthorsTitleYearFull text
Dr Alan Cartmell
Dr Jose Munoz Munoz
Dr Jonathan Briggs
Dr Didier Ndeh
Dr Elisabeth Lowe
et al.
Author Correction: A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation2019
Dr Alan Cartmell
Dr Jose Munoz Munoz
Dr Jonathan Briggs
Dr Didier Ndeh
Dr Elisabeth Lowe
et al.
A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status forarabinogalactan degradation2018
Yan Zhu
Emeritus Professor Harry Gilbert
Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif2018
Dr Didier Ndeh
Emeritus Professor Harry Gilbert
Biochemistry of complex glycan depolymerisation by the human gut microbiota2018
Dr Jonathan Briggs
Xiaoyang Zhang
Dr Didier Ndeh
Dr Aurore Labourel
Dr Arnaud Basle
et al.
Dietary pectic glycans are degraded by coordinated enzyme pathways in human colonic Bacteroides2018
Emeritus Professor Harry Gilbert
Expression system for structural and functional studies of human glycosylation enzymes2018
Emeritus Professor Harry Gilbert
Expression system for structural and functional studies of human glycosylation enzymes2018
Emeritus Professor Harry Gilbert
Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction2018
Emeritus Professor Harry Gilbert
PULDB: The expanded database of Polysaccharide Utilization Loci2018
Kate Cameron
Emeritus Professor Harry Gilbert
Structure-function analyses generate novel specificities to assemble the components of multienzyme bacterial cellulosome complexes2018
Dr Arnaud Basle
Emeritus Professor Harry Gilbert
Dr Didier Ndeh
Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)2018
Dr Max Temple
Dr Fiona Cuskin
Dr Arnaud Basle
Emeritus Professor Harry Gilbert
Dr Elisabeth Lowe
et al.
A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: unique substrate conformation drives specificity of the key endo-1,6-β-glucanase2017
Dr Jose Munoz Munoz
Dr Alan Cartmell
Dr Arnaud Basle
Emeritus Professor Harry Gilbert
An evolutionarily distinct family of polysaccharide lyases removes rhamnose capping of complex arabinogalactan proteins2017
Emeritus Professor Harry Gilbert
Assembly of Ruminococcus flavefaciens cellulosome revealed by structures of two cohesin-dockerin complexes2017
Dr Didier Ndeh
Dr Artur Rogowski
Dr Alan Cartmell
Ana De Jesus Vaz Luís
Dr Arnaud Basle
et al.
Complex pectin metabolism by gut bacteria reveals novel catalytic functions2017
Emeritus Professor Harry Gilbert
Complexity of the Ruminococcus flavefaciens FD-1 cellulosome reflects an expansion of family-related protein-protein interactions2017
Dr Alan Cartmell
Dr Elisabeth Lowe
Dr Arnaud Basle
Dr Susan Firbank
Dr Didier Ndeh
et al.
How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans2017
Dr Artur Rogowski
Carl Morland
Emeritus Professor Harry Gilbert
Systems analysis in Cellvibrio japonicus resolves predicted redundancy of β-glucosidases and determines essential physiological functions2017
Dr Jose Munoz Munoz
Dr Alan Cartmell
Emeritus Professor Harry Gilbert
Unusual active site location and catalytic apparatus in a glycoside hydrolase family2017
Emeritus Professor Harry Gilbert
A Novel Carbohydrate-binding Module from Sugar Cane Soil Metagenome Featuring Unique Structural and Carbohydrate Affinity Properties2016
Dr Fiona Cuskin
Emeritus Professor Harry Gilbert
A β-Mannanase with a Lysozyme-like Fold and a Novel Molecular Catalytic Mechanism2016
Dr Alan Cartmell
Dr Jose Munoz Munoz
Emeritus Professor Harry Gilbert
Analysis Human Microbiome Reveals a New Glycoside Hydrolase Family, Which Lacks the Canonical Catalytic Apparatus2016
Dr Jose Munoz Munoz
Dr Alan Cartmell
Emeritus Professor Harry Gilbert
Bacteroides thetaiotaomicron requires rhamnose release to grow with Gum Arabic2016
Dr Imma Venditto
Ana De Jesus Vaz Luís
Dr Arnaud Basle
Emeritus Professor Harry Gilbert
Professor William Willats
et al.
Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition2016
Benedita Pinheiro
Kate Cameron
Dr Fiona Cuskin
Emeritus Professor Harry Gilbert
Diverse specificity of cellulosome attachment to the bacterial cell surface2016
Emeritus Professor Harry Gilbert
Editorial overview: Carbohydrate–protein interactions and glycosylation: integrating structural biology, informatics and systems modelling to understand glycan structure and glycan-protein interactions2016
Dr Elisabeth Lowe
Dr Fiona Cuskin
Dr Max Temple
Dr Arnaud Basle
Emeritus Professor Harry Gilbert
et al.
Fungal cell wall glucan metabolism by Bacteroides in the human gut2016
Dr Fiona Cuskin
Dr Lucy Crouch
Dr Arnaud Basle
Dr David Bolam
Emeritus Professor Harry Gilbert
et al.
Pivotal alpha mannosidase generates specificity for N-glycans through requirement for GlcNac at+2 subsite.2016
Emeritus Professor Harry Gilbert
Single Binding Mode Integration of Hemicellulose-degrading Enzymes via Adaptor Scaffoldins in Ruminococcus flavefaciens Cellulosome2016
Dr Imma Venditto
Ana De Jesus Vaz Luís
Dr Julia Schuckel
Dr Arnaud Basle
Emeritus Professor Harry Gilbert
et al.
The complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition2016
Dr Lucy Crouch
Dr Aurore Labourel
Emeritus Professor Harry Gilbert
The contribution of non-catalytic carbohydrate binding modules to the activity lytic polysaccharide monooxygenases2016
Dr Aurore Labourel
Dr Lucy Crouch
Dr Adam Jackson
Dr Artur Rogowski
Dr Joseph Gray
et al.
The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans2016
Emeritus Professor Harry Gilbert
Dr Didier Ndeh
Dr Artur Rogowski
Dr Fiona Cuskin
Dr Elisabeth Lowe
et al.
Understanding complex glycan utilization in the human microbiota2016
Emeritus Professor Harry Gilbert
Automatic prediction of polysaccharide utilization loci in Bacteroidetes species2015
Emeritus Professor Harry Gilbert
Carbohydrate-binding module assisting glycosynthase-catalysed polymerizations2015
Kate Cameron
Dr Helen Waller
Emeritus Professor Harry Gilbert
Cell-surface Attachment of Bacterial Multienzyme Complexes Involves Highly Dynamic Protein-Protein Anchors2015
Emeritus Professor Harry Gilbert
Dr Fiona Cuskin
Dr Elisabeth Lowe
Coevolution of yeast mannan digestion: Convergence of the civilized human diet, distal gut microbiome, and host immunity2015
Kate Cameron
Emeritus Professor Harry Gilbert
Combined Crystal Structure of a Type I Cohesin: Mutation and Affinity Binding Studies Reveal Structural Determinants of Cohesin-Dockerin Specificities2015
Dr Max Temple
Emeritus Professor Harry Gilbert
Evidence for a Boat Conformation at the Transition State of GH76 α Normal 0 false false false EN-GB X-NONE X-NONE -1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism2015
Dr Imma Venditto
Ana De Jesus Vaz Luís
Emeritus Professor Harry Gilbert
Family 46 Carbohydrate-binding Modules Contribute to the Enzymatic Hydrolysis of Xyloglucan and β-1,3–1,4-Glucans through Distinct Mechanisms2015
Dr Artur Rogowski
Jon Briggs
Dr Elisabeth Lowe
Dr Arnaud Basle
Carl Morland
et al.
Glycan complexity dictates microbial resource allocation in the large intestine2015
Dr Fiona Cuskin
Dr Elisabeth Lowe
Dr Max Temple
Dr Alan Cartmell
Dr Artur Rogowski
et al.
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism2015
Dr Artur Rogowski
Carl Morland
Dr Alan Cartmell
Dr Lucy Crouch
Dr Aurore Labourel
et al.
Recognition of xyloglucan by the crystalline cellulose-binding site of a family 3a carbohydrate-binding module2015
Dr Fiona Cuskin
Emeritus Professor Harry Gilbert
Structure of the GH76 alpha-mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron2015
Dr Fiona Cuskin
Dr Arnaud Basle
Dr Alison Day
Emeritus Professor Harry Gilbert
Dr Elisabeth Lowe
et al.
The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan2015
Thabata Alvarez
Emeritus Professor Harry Gilbert
Cloning, purification, crystallization and preliminary X-ray studies of a carbohydrate-binding module (CBM_E1) derived from sugarcane soil metagenome2014
Dr Adam Jackson
Dr Elisabeth Lowe
Emeritus Professor Harry Gilbert
Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate2014
Emeritus Professor Harry Gilbert
Editorial overview: Carbohydrate-protein interactions: The future is taking shape2014
Dr Artur Rogowski
Dr Arnaud Basle
Dr Alexandra Solovyova
Emeritus Professor Harry Gilbert
Dr David Bolam
et al.
Evidence That GH115 alpha-Glucuronidase Activity, Which Is Required to Degrade Plant Biomass, Is Dependent on Conformational Flexibility2014
Emeritus Professor Harry Gilbert
Mechanistic Strategies for Catalysis Adopted by Evolutionary Distinct Family 43 Arabinanases2014
Emeritus Professor Harry Gilbert
Recovery and fine structure variability of RGII sub-domains in wine (Vitis vinifera Merlot)2014
Emeritus Professor Harry Gilbert
Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of Glycoside Hydrolase2014
Dr Lucy Crouch
Dr Aurore Labourel
Emeritus Professor Harry Gilbert
Systems biology defines the biological significance of redox-active proteins during cellulose degradation in an aerobic bacterium2014
Xiaoyang Zhang
Dr Artur Rogowski
Emeritus Professor Harry Gilbert
Understanding How the Complex Molecular Architecture of Mannan-degrading Hydrolases Contributes to Plant Cell Wall Degradation2014
Emeritus Professor Harry Gilbert
Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules2013
Dr Max Temple
Emeritus Professor Harry Gilbert
Overproduction, purification, crystallization and preliminary X-ray characterization of the C-terminal family 65 carbohydrate-binding module (CBM65B) of endoglucanase Cel5A from Eubacterium cellulosolvens2013
Dr Adam Jackson
Emeritus Professor Harry Gilbert
The Structure of a Streptomyces avermitilis alpha-L-Rhamnosidase Reveals a Novel Carbohydrate-binding Module CBM67 within the Six-domain Arrangement2013
Dr Max Temple
Dr Artur Rogowski
Dr Arnaud Basle
Emeritus Professor Harry Gilbert
Understanding How Noncatalytic Carbohydrate Binding Modules Can Display Specificity for Xyloglucan2013
Emeritus Professor Harry Gilbert
Escherichia coli Expression, Purification, Crystallization, and Structure Determination of Bacterial Cohesin–Dockerin Complexes2012
Emeritus Professor Harry Gilbert
Designer-oligosaccharide microarrays to decipher ligands in mammalian and prokaryotic glucan-recognition systems2012
Dr Fiona Cuskin
Dr James Flint
Carl Morland
Dr Arnaud Basle
Dr Alexandra Solovyova
et al.
How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity2012
Dr Adam Jackson
Emeritus Professor Harry Gilbert
Influence of a Mannan Binding Family 32 Carbohydrate Binding Module on the Activity of the Appended Mannanase2012
Dr Artur Rogowski
Dr Adam Jackson
Professor Rick Lewis
Emeritus Professor Harry Gilbert
Dr Jon Marles-Wright
et al.
Introducing endo-xylanase activity into an exo-acting arabinofuranosidase that targets side chains2012
Dr David Bolam
Emeritus Professor Harry Gilbert
Novel Clostridium thermocellum Type I Cohesin-Dockerin Complexes Reveal a Single Binding Mode2012
Emeritus Professor Harry Gilbert
The Reaction Coordinate of a Bacterial GH47 alpha-Mannosidase: A Combined Quantum Mechanical and Structural Approach2012
Cedric Montanier
Dr James Flint
Dr Arnaud Basle
Professor Rick Lewis
Emeritus Professor Harry Gilbert
et al.
A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization2011
Dr Elisabeth Lowe
Emeritus Professor Harry Gilbert
Dr David Bolam
Recognition and degradation of plant cell wall polysaccharides by two human gut symbionts2011
Emeritus Professor Harry Gilbert
Structural and enzymatic characterization of a glycoside hydrolase family 31 alpha-xylosidase from Cellvibrio japonicus involved in xyloglucan saccharification2011
Alan Cartmell
Emeritus Professor Harry Gilbert
Structural insights into a unique cellulase fold and mechanism of cellulose hydrolysis2011
Professor Rick Lewis
Emeritus Professor Harry Gilbert
Structure and Function of an Arabinoxylan-specific Xylanase2011
Dr Morten Nielsen
Dr Louise Tailford
Dr James Flint
Dr Claire Dumon
Emeritus Professor Harry Gilbert
et al.
Substrate and Metal Ion Promiscuity in Mannosylglycerate Synthase2011
Alan Cartmell
Lauren McKee
Professor Rick Lewis
Emeritus Professor Harry Gilbert
Dr Jon Marles-Wright
et al.
The Structure and Function of an Arabinan-specific α-1,2-Arabinofuranosidase Identified from Screening the Activities of Bacterial GH43 Glycoside Hydrolases2011
Dr Artur Rogowski
Emeritus Professor Harry Gilbert
Carbohydrate-binding modules promote the enzymatic deconstruction of intact plant cell walls by targeting and proximity effects2010
Cedric Montanier
Dr James Flint
Dr David Bolam
He Fang Xie
Ziyuan Liu
et al.
Circular Permutation Provides an Evolutionary Link between Two Families of Calcium-dependent Carbohydrate Binding Modules2010
Dr Claire Dumon
Emeritus Professor Harry Gilbert
Mechanistic insights into a Ca2+-dependent family of α-mannosidases in a human gut symbiont2010
Professor Liam Donaldson
Dr Artur Rogowski
Emeritus Professor Harry Gilbert
Professor William Willats
Restricted access of proteins to mannan polysaccharides in intact plant cell walls2010
Cedric Montanier
Dr Claire Dumon
Dr James Flint
Emeritus Professor Harry Gilbert
Signature Active Site Architectures Illuminate the Molecular Basis for Ligand Specificity in Family 35 Carbohydrate Binding Module2010
Yan Zhu
Emeritus Professor Harry Gilbert
Structure and Kinetic Investigation of Streptococcus pyogenes Family GH38 alpha-Mannosidase2010
Dr Artur Rogowski
Alan Cartmell
Emeritus Professor Harry Gilbert
Analysis of the Structural and Functional Diversity of Plant Cell Wall Specific Family 6 Carbohydrate Binding Modules2009
Emeritus Professor Harry Gilbert
Developmental complexity of arabinan polysaccharides and their processing in plant cell walls2009
Dr Artur Rogowski
Emeritus Professor Harry Gilbert
Enzymatic treatments reveal differential capacities for xylan recognition and degradation in primary and secondary plant cell walls2009
Dr Claire Dumon
Dr James Flint
Dr Susan Firbank
Professor Rick Lewis
Emeritus Professor Harry Gilbert
et al.
Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function2009
Emeritus Professor Harry Gilbert
Dr David Bolam
Family 6 carbohydrate-binding modules display multiple beta 1,3-linked glucan-specific binding interfaces2009
Benedita Pinheiro
Emeritus Professor Harry Gilbert
Dr David Bolam
Functional insights into the role of novel type I cohesin and dockerin domains from Clostridium thermocellum2009
Dr Kaveh Emami
Dr Topakas Topakas
Tibor Nagy
Joanna Henshaw
Dr Kelly Jackson
et al.
Regulation of the xylan-degrading apparatus of Cellvibrio japonicus by a novel two-component system2009
Cedric Montanier
Dr James Flint
Benedita Pinheiro
Carl Morland
Alan Cartmell
et al.
The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions2009
Dr Louise Tailford
Dr James Flint
Carl Morland
Emeritus Professor Harry Gilbert
Understanding How Diverse beta-Mannanases Recognize Heterogeneous Substrates2009
Emeritus Professor Harry Gilbert
Complete genome sequence of the complex carbohydrate-degrading marine bacterium, Saccharophagus degradans strain 2-40T2008
Dr Joseph Newman
Professor Rick Lewis
Emeritus Professor Harry Gilbert
Dr James Flint
Crystal structure of a cellulosomal family 3 carbohydrate esterase from Clostridium thermocellum provides insights into the mechanism of substrate recognition2008
Dr Claire Dumon
Dr James Flint
Professor Rick Lewis
Professor Jeremy Lakey
Carl Morland
et al.
Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure2008
Emeritus Professor Harry Gilbert
How the walls come crumbling down: recent structural biochemistry of plant polysaccharide degradation2008
Dr Louise Tailford
Emeritus Professor Harry Gilbert
Insights into plant cell wall degradation from the genome sequence of the soil bacterium Cellvibrio japonicus2008
Alan Cartmell
Emeritus Professor Harry Gilbert
Probing the β-1,3:1,4 glucanase, CtLic26A, with a thio-oligosaccharide and enzyme variants2008
Dr Louise Tailford
Dr Claire Dumon
Carl Morland
Emeritus Professor Harry Gilbert
Structural and biochemical evidence for a boat-like transition state in β-mannosidases2008
Emeritus Professor Harry Gilbert
Sus out Sugars in2008
Alan Cartmell
Dr Topakas Topakas
Emeritus Professor Harry Gilbert
The Cellvibrio japonicus mannanase CjMan26C displays a unique exo-mode of action that is conferred by subtle changes to the distal region of the active site2008
Benedita Pinheiro
Dr Mark Proctor
Emeritus Professor Harry Gilbert
The Clostridium cellulolyticum Dockerin Displays a Dual Binding Mode for Its Cohesin Partner2008
Emeritus Professor Harry Gilbert
Cellulosomes: Microbial nanomachines that display plasticity in quaternary structure2007
Tibor Nagy
Emeritus Professor Harry Gilbert
Characterization of a Double Dockerin from the Cellulosome of the Anaerobic Fungus Piromyces equi2007
Tibor Nagy
Dr Mark Proctor
Emeritus Professor Harry Gilbert
Evidence for a dual binding mode of dockerin modules to cohesins2007
Dr Louise Tailford
Dr Claire Dumon
Emeritus Professor Harry Gilbert
Mannose foraging by Bacteroides thetaiotaomicron: Structure and specificity of the β-mannosidase, BtMan2A2007
Emeritus Professor Harry Gilbert
Novel xylan-binding properties of an engineered family 4 carbohydrate-binding module2007
Emeritus Professor Harry Gilbert
Promiscuous, non-catalytic, tandem carbohydrate-binding modules modulate the cell-wall structure and development of transgenic tobacco (Nicotiana tabacum) plants2007
Dr David Bolam
Dr Mark Proctor
Emeritus Professor Harry Gilbert
The crystal structure of two macrolide glycosyltransferases provides a blueprint for host cell antibiotic immunity2007
Dr James Flint
Dr David Bolam
Emeritus Professor Harry Gilbert
Differential recognition of plant cell walls by microbial xylan-specific carbohydrate-binding modules2006
Dr Louise Tailford
Emeritus Professor Harry Gilbert
Enzymatic fingerprinting of Arabidopsis pectic polysaccharides using polysaccharide analysis by carbohydrate gel electrophoresis (PACE)2006
Joanna Henshaw
Dr David Bolam
Emeritus Professor Harry Gilbert
Family 6 carbohydrate binding modules in β-agarases display exquisite selectivity for the non-reducing termini of agarose chains2006
Carl Morland
Dr Louise Tailford
Emeritus Professor Harry Gilbert
Galactomannan hydrolysis and mannose metabolism in Cellvibrio mixtus2006
Dr Mark Proctor
Dr David Bolam
Emeritus Professor Harry Gilbert
Insights into the Synthesis of Lipopolysaccharide and Antibiotics through the Structures of Two Retaining Glycosyltransferases from Family GT42006
Emeritus Professor Harry Gilbert
Novel modular enzymes encoded by a cellulase gene cluster in Cellvibrio mixtus2006
He Fang Xie
Dr James Flint
Professor Jeremy Lakey
Professor Rick Lewis
Emeritus Professor Harry Gilbert
et al.
Probing the Structural Basis for the Difference in Thermostability Displayed by Family 10 Xylanases2006
Dr Edward Taylor
Emeritus Professor Harry Gilbert
Structural insight into the ligand specificity of a thermostable family 51 arabinofuranosidase, Araf51, from Clostridium thermocellum2006
Emeritus Professor Harry Gilbert
Substrate distortion by a lichenase highlights the different conformational itineraries harnessed by related glycoside hydrolases2006
Dr James Flint
Dr David Bolam
Emeritus Professor Harry Gilbert
Understanding the biological rationale for the diversity of cellulose-directed carbohydrate-binding modules in prokaryotic enzymes2006
Emeritus Professor Harry Gilbert
Dr David Bolam
Xyloglucan is recognized by carbohydrate-binding modules that interact with β-glucan chains2006
Dr James Flint
Professor Rick Lewis
Emeritus Professor Harry Gilbert
Dr James Murray
A family 10 Thermoascus aurantiacus xylanase utilizes arabinose decorations of xylan as significant substrate specificity determinants2005
Carl Morland
Emeritus Professor Harry Gilbert
Family 6 carbohydrate binding modules recognize the non-reducing end of β-1,3-linked glucans by presenting a unique ligand binding surface2005
Dr Natalie Ferry
Carl Morland
Emeritus Professor Harry Gilbert
How family 26 glycoside hydrolases orchestrate catalysis on different polysaccharides: Structure and activity of a Clostridium thermocellum lichenase, CtLic26A2005
Dr Alexandra Carvalho
Emeritus Professor Harry Gilbert
Insights into the structural determinants of cohesin - Dockerin specificity revealed by the crystal structure of the type II cohesin from Clostridium thermocellum SdbA2005
Gavin Pell
Emeritus Professor Harry Gilbert
Mycobacterium tuberculosis strains possess functional cellulases2005
Dr Mark Proctor
Dr David Bolam
Emeritus Professor Harry Gilbert
Probing the breadth of macrolide glycosyltransferases: In vitro remodeling of a polyketide antibiotic creates active bacterial uptake and enhances potency2005
Dr James Flint
Dr David Bolam
Dr Edward Taylor
Emeritus Professor Harry Gilbert
Probing the mechanism of ligand recognition in family 29 carbohydrate-binding modules2005
Dr James Flint
Dr David Bolam
Dr Louise Tailford
Emeritus Professor Harry Gilbert
Structural dissection and high-throughput screening of mannosylglycerate synthase2005
Dr David Bolam
Gavin Pell
Emeritus Professor Harry Gilbert
Structure of a mannan-specific family 35 carbohydrate-binding module: Evidence for significant conformational changes upon ligand binding2005
Dr Mark Proctor
Dr Edward Taylor
Dr Ruth Lloyd
Emeritus Professor Harry Gilbert
Tailored catalysts for plant cell-wall degradation: Redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A2005
Dr Mark Proctor
Dr Edward Taylor
Dr Ruth Lloyd
Emeritus Professor Harry Gilbert
Tailored catalysts for plant cell-wall degradation: redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A2005
Dr Trudy Netherwood
Professor Anthony O'Donnell
Professor John Mathers
Emeritus Professor Harry Gilbert
Assessing the survival of transgenic plant DNA in the human gastrointestinal tract2004
Dr David Bolam
Emeritus Professor Harry Gilbert
Carbohydrate-binding modules: Fine-tuning polysaccharide recognition2004
Carl Morland
Emeritus Professor Harry Gilbert
Common inhibition of both β-glucosidases and β-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis2004
Emeritus Professor Harry Gilbert
Dr David Bolam
Glycoside hydrolase carbohydrate-binding modules as molecular probes for the analysis of plant cell wall polymers2004
Emeritus Professor Harry Gilbert
Inactivated enzymes as probes of the structure of arabinoxylans as observed by atomic force microscopy2004
Emeritus Professor Harry Gilbert
Professor Anthony O'Donnell
Professor John Mathers
'Informative' horizontal gene transfer2004
Gavin Pell
Dr Louise Tailford
Emeritus Professor Harry Gilbert
Insights into the molecular determinants of substrate specificity in glycoside hydrolase family 5 revealed by the crystal structure and kinetics of Cellvibrio mixtus mannosidase 5A2004
Dr James Flint
Emeritus Professor Harry Gilbert
Dr David Bolam
Ligand-mediated dimerization of a carbohydrate-binding module reveals a novel mechanism for protein-carbohydrate recognition2004
Dr David Bolam
Emeritus Professor Harry Gilbert
Reduction of starch granule size by expression of an engineered tandem starch-binding domain in potato plants2004
Gavin Pell
Lorand Szabo
He Fang Xie
Emeritus Professor Harry Gilbert
Structural and biochemical analysis of Cellvibrio japonicus Xylanase 10C: How variation in substrate-binding cleft influences the catalytic profile of family GH-10 xylanases2004
Joanna Henshaw
Dr David Bolam
Emeritus Professor Harry Gilbert
The crystal structure of the family 6 carbohydrate binding module from Cellvibrio mixtus endoglucanase 5A in complex with oligosaccharides reveals two distinct binding sites with different ligand specificities2004
Emeritus Professor Harry Gilbert
The dual nature of the wheat xylanase protein inhibitor XIP-I: Structural basis for the inhibition of family 10 and family 11 xylanases2004
Dr David Bolam
Emeritus Professor Harry Gilbert
The family 11 carbohydrate-binding module of Clostridium thermocellum Lic26A-Cel5E accommodates β-1,4- and β-1,3-1,4-mixed linked glucans at a single binding site2004
Joanna Henshaw
Dr David Bolam
Emeritus Professor Harry Gilbert
The family 6 carbohydrate binding module CmCBM6-2 contains two ligand-binding sites with distinct specificities2004
Gavin Pell
Dr Edward Taylor
Tibor Nagy
Emeritus Professor Harry Gilbert
The Mechanisms by Which Family 10 Glycoside Hydrolases Bind Decorated Substrates2004
Emeritus Professor Harry Gilbert
The N-terminal family 22 carbohydrate-binding module of xylanase 10B of Clostridium themocellum is not a thermostabilizing domain2004
Simon Andrews
Dr Edward Taylor
Gavin Pell
Professor Jeremy Lakey
Emeritus Professor Harry Gilbert
et al.
The use of forced protein evolution to investigate and improve stability of family 10 xylanases: The production of Ca2+independent stable xylanases2004
Dr David Bolam
Gavin Pell
Deborah Hogg
Greta Galbraith
Emeritus Professor Harry Gilbert
et al.
X4 modules represent a new family of carbohydrate-binding modules that display novel properties2004
Emeritus Professor Harry Gilbert
Cel6A, a major exoglucanase from the cellulosome of the anaerobic fungi Piromyces sp. E2 and Piromyces equi2003
Emeritus Professor Harry Gilbert
Cell, a noncellulosomal family 9 enzyme from Clostridium thermocellum, is a processive endoglucanase that degrades crystalline cellulose2003
Tibor Nagy
Emeritus Professor Harry Gilbert
Cellulosome assembly revealed by the crystal structure of the cohesin-dockerin complex2003
Gavin Pell
Emeritus Professor Harry Gilbert
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases2003
Lorand Szabo
Emeritus Professor Harry Gilbert
Expansion of the glycosynthase repertoire to produce defined manno-oligosaccharides2003
Emeritus Professor Harry Gilbert
How carbohydrate binding modules overcome ligand complexity2003
Gavin Pell
Huamao Du
Emeritus Professor Harry Gilbert
Dr David Bolam
Importance of hydrophobic and polar residues in ligand binding in the family 15 carbohydrate-binding module from Cellvibrio japonicus Xyn10C2003
Gavin Pell
Emeritus Professor Harry Gilbert
Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9 Å resolution2003
Deborah Hogg
Gavin Pell
Emeritus Professor Harry Gilbert
The modular architecture of Cellvibrio japonicus mannanases in glycoside hydrolase families 5 and 26 points to differences in their role in mannan degradation2003
Tibor Nagy
Professor Jeremy Lakey
Dr David Bolam
Emeritus Professor Harry Gilbert
The α-Glucuronidase, GlcA67A, of Cellvibrio japonicus utilizes the carboxylate and methyl groups of aldobiouronic acid as important substrate recognition determinants2003
Emeritus Professor Harry Gilbert
Dr David Bolam
Calcium binding and thermostability of carbohydrate binding module CBM4-2 of Xyn10A from Rhodothermus marinus2002
Emeritus Professor Harry Gilbert
Cellvibrio japonicus alpha-L-arabinanase 43A has a novel five-blade beta-propeller fold2002
Professor Anthony O'Donnell
Dr Trudy Netherwood
Emeritus Professor Harry Gilbert
Professor John Mathers
Degradation of transgenic DNA from genetically modified soya and maize in human intestinal simulations2002
Dr Kaveh Emami
Tibor Nagy
Emeritus Professor Harry Gilbert
Evidence for temporal regulation of the two Pseudomonas cellulosa xylanases belonging to glycoside hydrolase family 112002
Dr David Bolam
Lorand Szabo
Dr Vincent McKie
Emeritus Professor Harry Gilbert
Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello-and mannohexaose2002
Emeritus Professor Harry Gilbert
Lorand Szabo
Substrate distortion by β-mannanase: Snapshots of the Michaelis and covalent-intermediate complexes suggest a B2,5 conformation for the transition state2002
Emeritus Professor Harry Gilbert
The major component of the cellulosomes of anaerobic fungi from the genus Piromyces is a family 48 glycoside hydrolase2002
Tibor Nagy
Dr Kaveh Emami
Emeritus Professor Harry Gilbert
The membrane-bound α-glucuronidase from Pseudomonas cellulosa hydrolyzes 4-O-methyl-D-glucuronoxylooligosaccharides but not 4-O-methyl-D-glucuronoxylan2002
Emeritus Professor Harry Gilbert
The solution structure of the CBM4-2 carbohydrate binding module from a thermostable Rhodothermus marinus xylanase2002
Tibor Nagy
Emeritus Professor Harry Gilbert
The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A2002
Marie-helene Beylot
Dr Kaveh Emami
Dr Vincent McKie
Emeritus Professor Harry Gilbert
Gavin Pell
et al.
Pseudomonas cellulosa expresses a single membrane-bound glycoside hydrolase family 51 arabinofuranosidase2001
Dr Vincent McKie
Emeritus Professor Harry Gilbert
A new family of rhamnogalacturonan lyases contains an enzyme that binds to cellulose2001
Dr David Bolam
Emeritus Professor Harry Gilbert
A Novel Carbohydrate-binding Protein Is a Component of the Plant Cell Wall-degrading Complex of Piromyces equi2001
Tibor Nagy
Emeritus Professor Harry Gilbert
Characterization of a cellulosome dockerin domain from the anaerobic fungus Piromyces equi2001
He Fang Xie
Emeritus Professor Harry Gilbert
Dr David Bolam
Clostridium thermocellum Xyn10B carbohydrate-binding module 22-2: The role of conserved amino acids in ligand binding2001
Deborah Hogg
Dr David Bolam
Dr Vincent McKie
Emeritus Professor Harry Gilbert
Crystal Structure of Mannanase 26A from Pseudomonas cellulosa and Analysis of Residues Involved in Substrate Binding2001
Dr David Bolam
Emeritus Professor Harry Gilbert
Evidence for synergy between family 2b carbohydrate binding modules in Cellulomonas fimi Xylanase 11A2001
Simon Andrews
Emeritus Professor Harry Gilbert
Influence of the aglycone region of the substrate binding cleft of Pseudomonas xylanase 10A on catalysis2001
Lorand Szabo
He Fang Xie
Dr David Bolam
Emeritus Professor Harry Gilbert
Structure of a Family 15 Carbohydrate-binding Module in Complex with Xylopentaose2001
Lorand Szabo
He Fang Xie
Dr David Bolam
Emeritus Professor Harry Gilbert
Structure of a family 15 carbohydrate-binding module in complex with xylopentaose: Evidence that xylan binds in an approximate 3-fold helical conformation2001
Marie-helene Beylot
Dr Vincent McKie
Emeritus Professor Harry Gilbert
The Pseudomonas cellulosa glycoside hydrolase family 51 arabinofuranosidase exhibits wide substrate specificity2001
Dr David Bolam
Emeritus Professor Harry Gilbert
The Location of the Ligand-binding Site of Carbohydrate-binding Modules That Have Evolved from a Common Sequence Is Not Conserved2001
Emeritus Professor Harry Gilbert
A comparison of enzyme-aided bleaching of softwood paper pulp using combinations of xylanase, mannanase and α-galactosidase2000
Emeritus Professor Harry Gilbert
Dr Vincent McKie
Tibor Nagy
Helen Fernandes
A novel Cellvibrio mixtus family 10 xylanase that is both intracellular and expressed under non-inducing conditions2000
Emeritus Professor Harry Gilbert
Carbohydrate-binding modules from a thermostable Rhodothermus marinus xylanase: Cloning, expression and binding studies2000
Emeritus Professor Harry Gilbert
Primary sequence and enzymic properties of two modular endoglucanases, Cel5A and Cel45A, from the anaerobic fungus Piromyces equi2000
Lorand Szabo
Tibor Nagy
Emeritus Professor Harry Gilbert
Solution structure of the CBM10 cellulose binding module from Pseudomonas Xylanase A2000
Simon Andrews
Professor Jeremy Lakey
Emeritus Professor Harry Gilbert
Substrate specificity in glycoside hydrolase family 10: Tyrosine 87 and leucine 314 play a pivotal role in discriminating between glucose and xylose binding in the proximal active site of pseudomonas cellulosa xylanase 10A2000
He Fang Xie
Dr David Bolam
Emeritus Professor Harry Gilbert
The structural basis for the ligand specificity of family 2 carbohydrate-binding modules2000
Dr David Bolam
Emeritus Professor Harry Gilbert
The X6 'thermostabilizing' domains of xylanases are carbohydrate-binding modules: Structure and biochemistry of the Clostridium thermocellum X6b domain2000
Lorand Szabo
Tibor Nagy
Emeritus Professor Harry Gilbert
Trp22, Trp24, and Tyr8 play a pivotal role in the binding of the family 10 cellulose-binding module from Pseudomonas xylanase A to insoluble ligands2000
Dr Alison Park
Emeritus Professor Harry Gilbert
α-Galactosidase A from Pseudomonas fluorescens subsp. cellulosa: Cloning, high level expression and its role in galactomannan hydrolysis2000
Emeritus Professor Harry Gilbert
A family 26 mannanase produced by Clostridium thermocellum as a component of the cellulosome contains a domain which is conserved in mannanases from anaerobic fungi1999
Dr David Bolam
Emeritus Professor Harry Gilbert
A family IIb xylan-binding domain has a similar secondary structure to a homologous family IIa cellulose-binding domain but different ligand specificity1999
Emeritus Professor Harry Gilbert
A modular cinnamoyl ester hydrolase from the anaerobic fungus Piromyces equi acts synergistically with xylanase and is part of a multiprotein cellulose-binding cellulase-hemicellulase complex1999
Professor Simi Ali
Emeritus Professor Harry Gilbert
Emeritus Professor Barry Hirst
Dr Judith Hall
Bacterial xylanase expression in mammalian cells and transgenic mice1999
Emeritus Professor Harry Gilbert
Crystallization and preliminary X-ray analysis of arabinanase A from Pseudomonas fluorescens subspecies cellulosa1999
Dr Trudy Netherwood
Professor Anthony O'Donnell
Emeritus Professor Harry Gilbert
Gene transfer in the gastrointestinal tract1999
Emeritus Professor Harry Gilbert
Homologous xylanases from Clostridium thermocellum: evidence for bi-functional activity, synergism between xylanase catalytic modules and the presence of xylan-binding domains in enzyme complexes1999
Dr Trudy Netherwood
Emeritus Professor Harry Gilbert
Professor Anthony O'Donnell
Probiotics shown to change bacterial community structure in the avian gastrointestinal tract1999
Emeritus Professor Harry Gilbert
The starch-binding domain from glucoamylase disrupts the structure of starch1999
Dr David Bolam
Emeritus Professor Harry Gilbert
The type II and X cellulose-binding domains of Pseudomonas xylanase A potentiate catalytic activity against complex substrates by a common mechanism1999
Dr David Bolam
Emeritus Professor Harry Gilbert
Pseudomonas cellulose-binding domains mediate their effects by increasing enzyme substrate proximity1998
Professor Dianne Ford
Professor David Thwaites
Professor Nicholas Simmons
Emeritus Professor Harry Gilbert
Emeritus Professor Barry Hirst
et al.
Substrate upregulation of the human small intestinal peptide transporter, hPepT11998
Carl Morland
Professor Anthony O'Donnell
Emeritus Professor Harry Gilbert
Calcium protects a mesophilic xylanase from proteinase inactivation and thermal unfolding1997
Dr David Bolam
Emeritus Professor Harry Gilbert
Cellulose binding domains and linker sequences potentiate the activity of hemicellulases against complex substrates1997
Dr David Bolam
Dr Richard Virden
Professor Jeremy Lakey
Emeritus Professor Harry Gilbert
Mannanase A from Pseudomonas fluorescens ssp. cellulosa is a retaining glycosyl hydrolase in which E212 and E320 are the putative catalytic residues1996