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Browsing publications by Professor Jaap Van Laar.

Newcastle AuthorsTitleYearFull text
Gill Wheater
Dr Mohsen Elshahaly
Dr Stephen Tuck
Dr Harish Datta
Professor Jaap Van Laar
et al.
Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, results from an exploratory, prospective study2018
Sadaf Atarod
Jean Norden
Louis Bibby
Dr Clare Lendrem
Dr Kim Pearce
et al.
Differential MicroRNA Expression Levels in Cutaneous Acute Graft-versus-Host Disease2018
Professor Jaap Van Laar
Evolution of serum cytokine profile after hematopoietic stem cell transplantation in systemic sclerosis patients2016
Professor Jaap Van Laar
Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic Sclerosis2014
Dr Marzena Ciechomska
Dr Steven O'Reilly
Monika Suwara
Professor Jaap Van Laar
MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF- β Activated Kinase 1 Binding Protein 1, Implications for Systemic Sclerosis2014
Professor Jaap Van Laar
Multicriteria decision analysis methods with 1000Minds for developing systemic sclerosis classification criteria2014
Dr Steven O'Reilly
Rachel Cant
Dr Marzena Ciechomska
James Finnigan
Professor Fiona Oakley
et al.
Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-kappa B2014
Gill Wheater
Dr Mohsen Elshahaly
Dr Stephen Tuck
Dr John Drury
Professor Jaap Van Laar
et al.
Bone marker reference range study: a comparison of the manufacturer’s reference range and laboratory healthy volunteer results to patients with rheumatoid arthritis2013
Dr Mohsen Elshahaly
Gill Wheater
Dr Stephen Tuck
Dr Harish Datta
Professor Fai Ng
et al.
Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, a B cell depleting monoclonal antibody (HORUS TRIAL)2013
Professor Jaap Van Laar
Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study2013
Dr Steven O'Reilly
Rachel Cant
Dr Marzena Ciechomska
Professor Jaap Van Laar
Interleukin-6: a new therapeutic target in systemic sclerosis?2013
Dr Marzena Ciechomska
Rachel Cant
James Finnigan
Professor Jaap Van Laar
Dr Steven O'Reilly
et al.
Role of toll-like receptors in systemic sclerosis2013
Professor Jaap Van Laar
Strontium ranelate: ready for clinical use as disease-modifying osteoarthritis drug?2013
Gill Wheater
Dr Mohsen Elshahaly
Dr Stephen Tuck
Dr Harish Datta
Professor Jaap Van Laar
et al.
The clinical utility of bone marker measurements in osteoporosis2013
Dr Nicola Fullard
Dr Steven O'Reilly
Professor Jaap Van Laar
David Faini
Julie Diboll
et al.
The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in Mice2013
Professor Jaap Van Laar
The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis2013
Dr Marzena Ciechomska
Christiaan Huigens
Tess Stanly
Dr Andreas Gessner
Professor Sophie Hambleton
et al.
Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors2013
Dr Thomas Huegle
Dr Steven O'Reilly
Rachel Simpson
Dr Venetia Bigley
Professor Matthew Collin
et al.
Tumor Necrosis Factor-Costimulated T Lymphocytes From Patients With Systemic Sclerosis Trigger Collagen Production in Fibroblasts2013
Professor Jaap Van Laar
KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor2012
Professor Jaap Van Laar
A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations2012
Professor Jaap Van Laar
A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis2012
Professor Jaap Van Laar
A multicentre study confirms CD226 gene association with SSc-related pulmonary fibrosis2012
Dr Marzena Ciechomska
Christiaan Huigens
Dr Andreas Gessner
Dr Steven O'Reilly
Professor Jaap Van Laar
et al.
A novel role of monocytes in the induction of profibrotic tissue-inhibitor of metalloproteinase-1 mediated by toll-like receptors stimulation in SSC2012
Professor Jaap Van Laar
Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Disease-Is It Now Ready for Prime Time?2012
Dr Thomas Huegle
Dr Kathryn White
Professor Jaap Van Laar
Cell-to-cell contact of activated mast cells with fibroblasts and lymphocytes in systemic sclerosis2012
Nadine Binai
Dr Steven O'Reilly
Dr Bridget Griffiths
Professor Jaap Van Laar
Differentiation Potential of CD14(+) Monocytes into Myofibroblasts in Patients with Systemic Sclerosis2012
Professor Jaap Van Laar
Direct vesicle transmission by mast cells to fibroblasts and lymphocytes in SSc2012
Professor Jaap Van Laar
Haematopoietic SCT in severe autoimmune diseases: updated guidelines of the European Group for Blood and Marrow Transplantation2012
Professor Jaap Van Laar
Haemopoietic stem-cell transplantation for systemic sclerosis2012
Professor Jaap Van Laar
High Dose Immunoablation and Autologous Hematopoietic Stem Cell Transplantation Versus Monthly Intravenous Pulse Therapy Cyclophosphamide in Severe Systemic Sclerosis2012
Professor Jaap Van Laar
Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up2012
Dr Vanessa Hogan
Philip Stocks
Professor Jaap Van Laar
Induction of long-term B-cell depletion in refractory rheumatoid arthritis patients preferentially affects autoreactive more than protective humoral immunity2012
Professor Jaap Van Laar
Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis2012
Dr Steven O'Reilly
Dr Marzena Ciechomska
Professor Jaap Van Laar
Interleukin-6, its role in fibrosing conditions2012
Dr Vanessa Hogan
Professor Jaap Van Laar
Pretreatment synovial transcriptional pro le is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab2012
Dr Arthur Pratt
Professor Jaap Van Laar
Rheumatoid arthritis: Pathogenesis and clinical aspects2012
Dr Steven O'Reilly
Dr Bridget Griffiths
Dr Anja Krippner-Heidenreich
Professor Jaap Van Laar
T cell derived IL-6 and IL-13 drive fibroblast fibrosis: Implications for systemic sclerosis2012
Dr Steven O'Reilly
Professor Jaap Van Laar
T cells in systemic sclerosis: a reappraisal2012
Professor Jaap Van Laar
The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis2012
Dr Mohsen Elshahaly
Gill Wheater
Dr Stephen Tuck
Dr Harish Datta
Professor Jaap Van Laar
et al.
The role of B cells in bone turnover in rheumatoid arthritis2012
Dr Marzena Ciechomska
Dr Andreas Gessner
Dr Steven O'Reilly
Professor Jaap Van Laar
Toll-like receptor-mediated expression of profibrotic tissue-inhibitor of metalloproteinase-1 by circulating monocytes in Systemic sclerosis2012
Professor Jaap Van Laar
A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort2011
Dr Rajan Madhok
Professor Jaap Van Laar
Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis2011
Dr Vanessa Hogan
Professor Jaap Van Laar
Changes in gene expression in synovial tissue from refractory rheumatoid arthritis patients treated with rituximab2011
Dr Vanessa Hogan
Professor Jaap Van Laar
Changes in gene expression in synovial tissue from refractory rheumatoid arthritis patients treated with rituximab2011
Professor Jaap Van Laar
Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population2011
Dr Andrew Russell
Professor Jaap Van Laar
Determination of smoking status of rheumatoid arthritis patients by means of a self-reported questionnaire and serum cotinine assay: a cross-sectional study2011
Professor Jaap Van Laar
EUSTAR biobanking: recommendations for the collection, storage and distribution of biospecimens in scleroderma research2011
Professor Jaap Van Laar
Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy2011
Professor Jaap Van Laar
Involvement of functional autoantibodies against vascular receptors in systemic sclerosis2011
Professor Jaap Van Laar
Is there a role for TNF-alpha antagonists in the treatment of SSc? EUSTAR expert consensus development using the Delphi technique2011
Dr Thomas Huegle
Professor Jaap Van Laar
Late onset systematic sclerosis: A systematic survey of the eular scleroderma trials and research group database2011
Dr Thomas Huegle
Professor Jaap Van Laar
Late-onset systemic sclerosis-a systematic survey of the EULAR scleroderma trials and research group database2011
Dr Thomas Huegle
Dr Vanessa Hogan
Dr Kathryn White
Professor Jaap Van Laar
Mast Cells Are a Source of Transforming Growth Factor β in Systemic Sclerosis2011
Professor Jaap Van Laar
Needs and preferences regarding health care delivery as perceived by patients with systemic sclerosis2011
Dr Vanessa Hogan
Professor Jaap Van Laar
Pretreatment Synovial Transcriptional Profile Predicts Early and Late Clinical Response in Rheumatoid Arthritis Patients Treated with Rituximab2011
Professor Jaap Van Laar
Randomized Comparison of a Multidisciplinary Team Care Program With Usual Care in Patients With Systemic Sclerosis2011
Nadine Binai
Dr Thomas Huegle
Professor Jaap Van Laar
Role of ET-1 and GM-CSF on the differentiation potential of monocytes in systematic sclerosis2011
Nadine Binai
Dr Thomas Huegle
Professor Jaap Van Laar
Role of ET-1 and GM-CSF on the differentiation potential of monocytes in systemic sclerosis2011
Gill Wheater
Dr Vanessa Hogan
Emeritus Professor Roger Francis
Dr Stephen Tuck
Dr Harish Datta
et al.
Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis2011
Gill Wheater
Dr Vanessa Hogan
Emeritus Professor Roger Francis
Dr Harish Datta
Professor Jaap Van Laar
et al.
Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis2011
Gill Wheater
Dr Vanessa Hogan
Emeritus Professor Roger Francis
Dr Harish Datta
Professor Jaap Van Laar
et al.
Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis2011
Dr Steven O'Reilly
Dr Thomas Huegle
Dr Anja Krippner-Heidenreich
Professor Jaap Van Laar
T cell-derived IL-6 and IL-13 drive dermal fibrosis: implications for systemic sclerosis2011
Dr Andreas Gessner
Tess Stanly
Dr Thomas Huegle
Professor Jaap Van Laar
TIMP-1 production by monocytes may contribute to SSC skin fibrosis2011
Dr Thomas Huegle
Dr Anja Krippner-Heidenreich
Rachel Simpson
Dr Steven O'Reilly
Dr Venetia Bigley
et al.
Tumour necrosis factor alpha receptor activated T cells of patients with systemic sclerosis are deficient in IL-10 expression but promote myofibroblast differentiation via IL-6 and TGF-beta2011
Dr Thomas Huegle
Professor Jaap Van Laar
Allogeneic stem cell transplantation for rheumatic autoimmune diseases2010
Dr Thomas Huegle
Dr Venetia Bigley
Professor Jaap Van Laar
Analysis of mononuclear cell subsets in dermis and blood of patients with systemic sclerosis by multicolour flow cytometry2010
Professor Jaap Van Laar
B-cell depletion with rituximab: a promising treatment for diffuse cutaneous systemic sclerosis2010
Professor Jaap Van Laar
Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: Results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database2010
Professor Jaap Van Laar
Clinical response, pharmacokinetics, development of human anti-chimeric antibodies, and synovial tissue response to rituximab treatment in patients with rheumatoid arthritis2010
Professor Jaap Van Laar
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus2010
Professor Jaap Van Laar
Immunesuppression in systematic sclerosis: Past, present and future2010
Professor Jaap Van Laar
Intranasal administration of recombinant Human Cartilage glycoprotein-39 as a treatment for rheumatoid arthritis: A Phase II, multicenter, double-blind, randomized, placebo-controlled, parallel group dose-finding trial2010
Professor Jaap Van Laar
Panel Session Report: Systemic Lupus Erythematosus2010
Professor Jaap Van Laar
Panel Session Report: Systemic Sclerosis2010
Professor Jaap Van Laar
Reply2010
Professor Jaap Van Laar
Sexual function in women with systemic sclerosis: comment on the article by Schouffoer et al [reply]2010
Professor Jaap Van Laar
Stem cells in the treatment of inflammatory arthritis2010
Gill Wheater
Dr Vanessa Hogan
Emeritus Professor Roger Francis
Dr Harish Datta
Professor Jaap Van Laar
et al.
Suppression of bone turnover by B-cell depletion in patients with rheumatoid arthritis (Premier Poster-Award Candidate)2010
Dr Thomas Huegle
Professor Jaap Van Laar
Allogeneic hematopoietic SCT for patients with autoimmune diseases2009
Professor Jaap Van Laar
ASTIS Trail2009
Professor Jaap Van Laar
Autologous hematopoietic stem cell transplantation (HSCT) for autoimmune diseases: an observational study on 12 years of experience from the European Group for Blood and Marrow Transplantation (EBMT) Working Party on Autoimmune Diseases2009
Professor Jaap Van Laar
Cytokine measurement before and after hematopoietic stem cell transplantation in severe diffuse systemic sclerosis2009
Professor Jaap Van Laar
Heart failure as presenting manifestation of cardiac involvement in systemic lupus erythematosus2009
Professor Jaap Van Laar
Impaired Sexual Function in Women With Systemic Sclerosis: A Cross-Sectional Study2009
Arie Huigens
Professor Jaap Van Laar
New pathogenic and therapeutic concepts in systemic sclerosis2009
Professor Jaap Van Laar
Residual inflammation after rituximab treatment is associated with sustained synovial plasma cell infiltration and enhanced B cell repopulation2009
Professor Jaap Van Laar
Rituximab fixed retreatment versus on-demand retreatment in refractory rheumatoid arthritis: comparison of two B cell depleting treatment strategies2009
Professor Jaap Van Laar
Systemic sclerosis and its pulmonary complications in the Netherlands: an epidemiological study.2009
Professor Jaap Van Laar
The clinical relevance of a repeat biopsy in lupus nephritis flares2009
Dr Thomas Huegle
Arie Huigens
Dr Lesley Ottewell
Dr Bridget Griffiths
Professor Jaap Van Laar
et al.
The role of fibrocytes in systemic sclerosis [Poster session]2009
Professor Jaap Van Laar
The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype2009
Alistair Brown
Professor Jaap Van Laar
Professor John Isaacs
Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse.2008
Professor Jaap Van Laar
Arthroscopic lavage plus corticosteroids is more effective than joint aspiration plus corticosteroids in patients with arthritis of the knee2008
Professor Jaap Van Laar
Autologous stem cell transplantation for severe systemic sclerosis: Update on the ASTIS-trial2008
Professor Jaap Van Laar
Autologous stem cell transplantation for systemic sclerosis2008
Professor Jaap Van Laar
CD20 epitope masking by rituximab: comment on the article by Gunnarsson et al2008
Professor Jaap Van Laar
Cellular therapy of systemic sclerosis2008
Professor Jaap Van Laar
Differences in synovial tissue infiltrates between anti-cyclic citrullinated peptide-positive rheumatoid arthritis and anti-cyclic citrullinated peptide-negative rheumatoid arthritis2008
Professor Jaap Van Laar
Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis.2008
Professor Jaap Van Laar
Rituximab fixed retreatment versus on-demand retreatment in refractory rheumatoid arthritis: Comparison of two B-cell depleting treatment strategies2008
Dr Thomas Huegle
Professor Jaap Van Laar
Stem cell transplantation for rheumatic autoimmune diseases2008
Professor Jaap Van Laar
Stem cell transplantation: a treatment option for severe systemic sclerosis?2008
Professor Jaap Van Laar
The ASTIS trial2008
Professor Jaap Van Laar
The Milwaukee shoulder/knee syndrome2008
Professor Jaap Van Laar
The role of B cells in systemic sclerosis2008
Professor Jaap Van Laar
Anticyclic citrullinated peptide antibodies: The footprint of autoreactive plasma cells in synovium?2007
Professor Jaap Van Laar
Cell therapy for autoimmune diseases2007
Professor Jaap Van Laar
Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study2007
Professor Jaap Van Laar
Do high levels of IgA rheumatoid factor indicate a poor response to treatment with TNF inhibitors in patients with RA?2007
Mukhtar Hashemi
Professor Jaap Van Laar
Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment2007
Professor Jaap Van Laar
Poor serological responses upon influenza vaccination in patients with rheumatoid arthritis treated with rituximab2007
Professor Jaap Van Laar
Scleroderma lung: pathogenesis, evaluation and current therapy2007
Professor Jaap Van Laar
Sustained Secretion of Immunoglobulin by Long-Lived Human Tonsil Plasma Cells2007
Professor Jaap Van Laar
Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation2007
Professor Jaap Van Laar
Pulmonary fibrosis in a patient with rheumatoid arthritis treated with adalimumab.2006
Professor Jaap Van Laar
Autologous Stem cell Transplantation International Scleroderma (ASTIS) trial: hope on the horizon for patients with severe systemic sclerosis2005
Professor Jaap Van Laar
Control of systemic B cell–mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex–mismatched allogeneic bone marrow transplantation2005
Professor Jaap Van Laar
Feasibility of allogeneic hematopoietic stem cell transplantation for autoimmune disease: position statement from a National Institute of Allergy and Infectious Diseases and narional Cancer Institute2005
Professor Jaap Van Laar
Long-Term Followup of Health Status in Patients With Severe Rheumatoid Arthritis After High-Dose Chemotherapy Followed by Autologous Hematopoietic Stem Cell Transplantation2005
Professor John Isaacs
Professor Jaap Van Laar
Outcome of intensive immunosuppression and autologous stem cell transplantation in patients with severe rheumatoid arthritis is associated with the composition of synovial T cell infiltration2005
Alistair Brown
Dr Prakash Patel
Professor Jaap Van Laar
Professor John Isaacs
Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia2004
Professor Jaap Van Laar
Professor John Isaacs
Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis2002
Professor Jaap Van Laar
High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation in Patients With Rheumatoid Arthritis Results of an Open Study to Assess Feasibility, Safety, and Efficacy2001