Toggle Main Menu Toggle Search

Open Access padlockePrints

Early nutrition: Impact on epigenetics

Lookup NU author(s): Professor John Mathers

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Background/Aims: (1) To outline the findings that alterations in nutrition in utero and in early postnatal life influence health in later life. (2) To review the evidence that alterations in epigenetic markings may be a means by which the genome records environmental (including nutritional) exposure resulting in changes in gene expression and cell function which underlie susceptibility to disease. Methods: Literature review. Results: There is strong evidence that low birth weight, especially when followed by accelerated growth in childhood and greater central adiposity in adulthood, is a risk factor for a range of common diseases including cardiovascular disease and type 2 diabetes. Such observations provide the basis for the 'programming' hypothesis and present a challenge to discover the mechanisms by which nutritional insults in early life are received, recorded, remembered and then revealed in later life. Emerging evidence suggests that alterations in epigenetic marking of the genome may be a key mechanism by which nutritional exposure in utero can influence gene expression, and therefore, phenotype. Conclusion: Early life nutrition has the potential to change chromatin structure, to alter gene expression and to modulate health throughout the life course. Whether later interventions can reverse adverse epigenetic markings remains to be discovered. Copyright (c) 2007 S. Karger AG, Basel.


Publication metadata

Author(s): Mathers JC

Editor(s): E. Shyong Tai; Peter J. Gillies

Publication type: Conference Proceedings (inc. Abstract)

Publication status: Published

Conference Name: Nutrigenomics - Opportunities in Asia: 1st ILSI International Conference on Nutrigenomics

Year of Conference: 2007

Pages: 42-48

ISSN: 1660–0347

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000107066

DOI: 10.1159/000107066

Library holdings: Search Newcastle University Library for this item

ISBN: 9783805582162


Share