Epidemiology of bone tumours in children and young adults

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  2. Rachel Eyre
  3. Richard Feltbower
  4. Emmanuel Mubwandarikwa
  5. Dr Richard McNally
Author(s)Eyre R, Feltbower RG, Mubwandarikwa E, Eden TO, McNally RJ
Publication type Article
JournalPediatric Blood and Cancer
Year2009
Volume53
Issue6
Pages941-952
ISSN (print)1545-5009
ISSN (electronic)1545-5017
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Although the epidemiology of malignant bone tumours in children and young adults has been explored, no definitive causation of any specific tumour has yet been identified. We performed a literature review (1970 – 2008) to find all papers covering possible aetiological factors involved in the development of bone tumours in children and young adults. Several associations have been reported with some consistency: the presence of hernias and Ewing sarcoma; high fluoride exposure and osteosarcoma; and parental farming and residence on a farm, younger age at puberty and family history of cancer for all bone tumours, especially osteosarcoma. Clearly further research is needed to confirm or refute these putative risk factors. It is likely that studies of gene-environment interactions may prove to be the most fruitful of future research.
PublisherJohn Wiley & Sons, Inc.
URLhttp://dx.doi.org/10.1002/pbc.22194
DOI10.1002/pbc.22194
PubMed id19618453
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