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Contrasting effects of steroids and angiotensin-converting-enzyme inhibitors in a mouse model of dystrophin-deficient cardiomyopathy

Lookup NU author(s): Professor Volker StraubORCiD, Dr Alison Blain, Emerita Professor Katherine Bushby, Dr Guy MacGowanORCiD

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Abstract

Duchenne muscular dystrophy (DMD) is associated with progressive cardiomyopathy. Oral corticosteroids are the gold standard for the treatment of skeletal muscle weakness; however, the effects of steroids on cardiac function have not been prospectively studied. In addition, the early role of ACE-inhibitors (ACE-I) is controversial. We aimed to determine the effects of steroids and ACE-I on development of left ventricular dysfunction in the mdx mouse, a model for dystrophin-deficient cardiomyopathy. Orally administered captopril or prednisolone was given for 8 weeks to 16-week-old, male mdx mice. In vivo pressure-volume loops, fibrosis, in vivo myocyte sarcolemmal injury, and cytokine expression were assessed in treated and untreated mdx mice and age-matched controls. Untreated mdx mice showed compensated cardiomyopathy with reduced myocardial contractility, patchy myocardial fibrosis but preserved stroke volume. Captopril treatment resulted in indirect myocardial effects of reduced afterload and direct effects of increased contractility. Prednisolone caused acute sarcolemmal injury, increased expression of myocardial TNF alpha and fibrosis, resulting in left ventricular dilatation and diastolic dysfunction. In a mouse model of dystrophin-deficient cardiomyopathy, ACE-I produced haemodynamic benefit, whereas steroids accelerated progression of cardiomyopathy. Although mouse models may not entirely replicate the human condition, comprehensive monitoring of cardiac function with these therapies is essential.

Publication metadata

Author(s): Bauer R, Straub V, Blain A, Bushby K, MacGowan GA

Publication type: Article

Publication status: Published

Journal: European Journal of Heart Failure

Year: 2009

Volume: 11

Issue: 5

Pages: 463-471

ISSN (print): 1388-9842

ISSN (electronic): 1879-0844

Publisher: Oxford University Press

URL: http://dx.doi.org/10.1093/eurjhf/hfp028

DOI: 10.1093/eurjhf/hfp028

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