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Flow minimal residue disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34
in B-lineage childhoood acute lymphoblastic leukemia
Lookup NU author(s)
Professor Simon Bailey
Dr Nicholas Bown
Professor Josef Vormoor
Professor Julie Irving
Wilson K, Case M, Minto L, Bailey S, Bown N, Jesson J, Lawson S, Vormoor J, Irving J
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Flow cytometric minimal residual disease (MRD) monitoring could become more powerful if directed towards the disease-maintaining leukaemic stem cell (LSC) compartment. Using a cohort of 48 children with B lineage acute lymphoblastic leukamia (ALL), we sought the newly proposed candidate-LSC population, CD34+CD38lowCD19+, at presentation and in end of induction bone marrow samples. We identified the candidate LSC population in 60% of diagnostic samples and its presence correlated with expression of CD38, relative to that of normal B cell progenitors. In addition, the candidate LSC was not detectable in all MRD positive samples. The absence of the population in 40% of diagnostic and 40% of MRD positive samples does not support the use of this phenotype as a generic biomarker to track LSCs and suggests that that this phenotype may be an artifact of CD38 under-expression rather than a biologically distinct LSC population.
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