Development of dendritic cell-based immunotherapy for autoimmunity

  1. Lookup NU author(s)
  2. Dr Catharien Hilkens
  3. Professor John Isaacs
Author(s)Hilkens CM, Isaacs JD, Thomson AW
Publication type Review
JournalInternational Reviews of Immunology
ISSN (print)0883-0185
ISSN (electronic)1563-5244
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic cell-based immunotherapies show great promise for the restoration of tolerance in autoimmune disease. Dendritic cells can be modified ex vivo to induce stable tolerogenic function and be used as cellular ‘vaccines’ or they can be targeted in vivo with sophisticated antigen delivery systems. Tolerogenic dendritic cells induce antigen-specific T-cell tolerance in vivo and have therapeutic effects in animal models of autoimmunity. The current challenge is to bring tolerogenic dendritic cell therapy to the clinic.
Actions    Link to this publication