About Open Access
A novel role for transcription factor Lmo4 in thymus development through genetic interaction with Cited2
Lookup NU author(s)
Dr Simon Bamforth
Michell A, Braganca J, Broadbent C, Joyce B, Franklyn A, Schneider JE, Bhattacharya S, Bamforth SD
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Deletion of the transcriptional modulator Cited2 in the mouse results in embryonic lethality, cardiovascularmalformations, adrenal agenesis, cranial ganglia fusion, exencephaly, and left–right patterningdefects, all seen with a varying degree of penetrance. The phenotypic heterogeneity, observed on differentgenetic backgrounds, indicates the existence of both genetic and environmental modifiers. Mice lackingthe LIM domain-containing protein Lmo4 share specific phenotypes with Cited2 null embryos, such as embryoniclethality, cranial ganglia fusion, and exencephaly. These shared phenotypes suggested that Lmo4may be a potential genetic modifier of the Cited2 phenotype. Examination of Lmo4-deficient embryosrevealed partially penetrant cardiovascular malformations and hypoplastic thymus. Examination ofLmo4;Cited2 compound mutants indicated that there is a genetic interaction between Cited2 and Lmo4 incontrol of thymus development. Our data suggest that this may occur, in part, through control of expressionof a common target gene, Tbx1, which is necessary for normal thymus development.
John Wiley & Sons, Inc.
Altmetrics provided by
Newcastle University Library, NE2 4HQ, United Kingdom. Tel: 0044 (191) 222 7657
©2017 Newcastle University Library