Efficient Cycloisomerisation of Propargyl Amides by Electrophilic Gold(I) Complexes of KITPHOS Monophosphines: A Comparative Study

  1. Lookup NU author(s)
  2. Dr Simon Doherty
  3. Dr Julian Knight
  4. Catherine Smyth
  5. Nicholas Ward
  6. S Parimala A Saminathan
  7. Emeritus Professor William Clegg
Author(s)Doherty S, Knight JG, Hashmi ASK, Smyth CS, Ward NAB, Robson KJ, Tweedley S, Harrington RW, Clegg W
Publication type Article
ISSN (print)0276-7333
ISSN (electronic)1520-6041
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Electrophilic gold(I) complexes of diphenyl- and dicyclohexylphosphino-based KITPHOS monophosphines catalyze the 5-exo-dig cycloisomerization of a range of propargyl amides to afford the corresponding alkylidene oxazolines; in all cases catalysts formed from diphenylphosphino-substituted KITPHOS monophosphines outperformed their dicyclohexylphosphino counterparts as well as that based on triphenylphosphine, an indication that the biaryl/biaryl-like framework may be responsible for imparting high catalyst efficiency.
PublisherAmerican Chemical Society
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