Efficient Cycloisomerisation of Propargyl Amides by Electrophilic Gold(I) Complexes of KITPHOS Monophosphines: A Comparative Study

  1. Lookup NU author(s)
  2. Dr Simon Doherty
  3. Dr Julian Knight
  4. Catherine Smyth
  5. Nicholas Ward
  6. Parimala Saminathan
  7. Emeritus Professor Bill Clegg
Author(s)Doherty S, Knight JG, Hashmi ASK, Smyth CS, Ward NAB, Robson KJ, Tweedley S, Harrington RW, Clegg W
Publication type Article
ISSN (print)0276-7333
ISSN (electronic)1520-6041
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Electrophilic gold(I) complexes of diphenyl- and dicyclohexylphosphino-based KITPHOS monophosphines catalyze the 5-exo-dig cycloisomerization of a range of propargyl amides to afford the corresponding alkylidene oxazolines; in all cases catalysts formed from diphenylphosphino-substituted KITPHOS monophosphines outperformed their dicyclohexylphosphino counterparts as well as that based on triphenylphosphine, an indication that the biaryl/biaryl-like framework may be responsible for imparting high catalyst efficiency.
PublisherAmerican Chemical Society
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