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How do changes in water quality and dialysate composition affect clinical outcomes?

Lookup NU author(s): Dr Nicholas Hoenich

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Abstract

Dialysis relies upon the transfer of waste products and electrolytes across a semi-permeable membrane contained in the dialyser facilitated by the dialysis fluid, a fast-flowing electrolyte solution prepared continuously by the mixing of treated water with a concentrated electrolyte solution. Both the water, the buffer and electrolyte composition play important roles in modulating complications associated with treatment. With respect to water, historically the focus was on chemical contaminant content, but more recently has shifted to microbiological quality due to the role that such quality plays in the pro-inflammatory state. The composition of the dialysis fluid is crucial in normalization of electrolyte composition of plasma water, homeostasis and acid-base balance, and should be individualized to the patients' requirements in the same way as blood and dialysate flow rates are individualized to ensure optimal comfort and minimal complications associated with the procedure. Copyright © 2009 S. Karger AG.


Publication metadata

Author(s): Hoenich NA, Levin R, Ronco C

Publication type: Article

Publication status: Published

Journal: Blood Purification

Year: 2009

Volume: 27

Issue: 1

Pages: 11-15

ISSN (print): 0253-5068

ISSN (electronic): 1421-9735

Publisher: S. Karger AG

URL: http://dx.doi.org/10.1159/000167002

DOI: 10.1159/000167002


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