Carboplatin and pemetrexed in the management of malignant pleural mesothelioma: a realistic treatment option?

  1. Lookup NU author(s)
  2. Dr Louise Li
Author(s)Li L, Razak AR, Hughes A
Publication type Article
JournalLung Cancer
Year2009
Volume64
Issue2
Pages207-210
ISSN (print)0169-5002
ISSN (electronic)1872-8332
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
BACKGROUND: Malignant pleural mesothelioma is an aggressive cancer. Chemotherapy with cisplatin and pemetrexed can improve overall survival but has a toxic profile. Substitution of cisplatin with carboplatin may avoid some potential side-effects. Therefore, we undertook a retrospective review to assess the effectiveness and tolerability of carboplatin and pemetrexed in patients with malignant pleural mesothelioma in clinical practice. METHODS: Patients with malignant pleural mesothelioma who had been treated with carboplatin and pemetrexed were retrospectively identified from pharmacy databases. The endpoints were disease control rate, time to treatment failure, clinical improvement rate and overall survival. We also evaluated any significant haematological and non-haematological toxicities. RESULTS: A total of 49 patients were identified. Of 45 evaluable cases, the disease control rate was achieved in 34 patients (69%, 95% CI 55-82, intention to treat analysis). The clinical response rate was achieved in 34 out of 49 patients (69%, 95% CI 55-82). The median time to treatment failure was 4.6 months (95% CI 3.4-5.8) and median overall survival was 14 months (95% CI 9.5-18.5). Grade 3/4 haematological toxicities were observed in 7 patients (14.3%). Grade 3/4 non-haematological toxicities were seen in 12 patients (24.5%). No toxic deaths were recorded. CONCLUSION: The combination of carboplatin and pemetrexed may be a viable option in the treatment of malignant pleural mesothelioma.
PublisherElsevier Ireland Ltd
URLhttp://dx.doi.org/10.1016/j.lungcan.2008.08.016
DOI10.1016/j.lungcan.2008.08.016
Actions    Link to this publication
Share