B lymphocytes acquire and present intracellular antigens that have relocated to the surface of apoptotic target cells

  1. Lookup NU author(s)
  2. Dr Marzena Ciechomska
  3. Professor Thomas Lennard
  4. Professor John Kirby
  5. Dr Andrew Knight
Author(s)Ciechomska M, Lennard TWJ, Kirby JA, Knight AM
Publication type Article
JournalEuropean Journal of Immunology
ISSN (print)0014-2980
ISSN (electronic)1521-4141
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
The induction of an effective immune response requires the activation of CD4+ T lymphocytes by APCs. While DCs have been shown to be pivotal in this process, it is now apparent that optimal CD4+ T-cell activation also requires B-lymphocyte APC function. Along with the acquisition of soluble antigens, it is known that B cells also acquire membrane-tethered antigens. Recent reports have described the relocation of intracellular antigens to the cell surface following immunogenic apoptosis. This study was designed to determine whether B cells can acquire and present such antigens to CD4+ T cells. By targeting the model antigen tetanus toxin C fragment to various cellular locations, we show that antigen-specific B cells acquire intracellular antigens that have relocated to the surface of cells undergoing immunogenic apoptosis. Crucially, we also demonstrate that antigen-specific B cells acquiring relocated antigen from apoptotic targets are capable of efficiently inducing CD4+ T-cell activation. We propose that the acquisition and presentation of intracellular antigens that have relocated to the cell surface during immunogenic apoptosis represents a novel means by which antigen-specific B cells contribute to the generation of immunity.
PublisherWiley - VCH Verlag GmbH & Co. KGaA
Actions    Link to this publication

Altmetrics provided by Altmetric