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HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus

Lookup NU author(s): Professor Marco Carrozzo

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Abstract

Objectives: Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft-versus-host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin-like receptor (KIR) genes encode a family of receptors expressed on NK and T cells and are supposed to play a significant role in GVHD and HCV infection. The aim of this study was to analyze the association among OLP, HCV infection and variants in KIR gene expression. Methods: A total of 81 patients with OLP (36 HCV+ve and 45 HCV-ve) and 217 healthy controls (HCV-ve) were typed for the presence of eight KIR genes and of HLA-Cw* alleles by polymerase chain reaction-sequence specific primer. Results: There were no significant differences in the frequency of the KIR genes and HLA-C1/C2 group alleles between cases and controls. We only found a significant difference in the frequency of the gene KIR2DL2 between HCV+ve and HCV-ve OLP patients. Conclusions: The present data suggest that OLP is not associated with particular KIR genes or with HLA-Cw* alleles in patients without HCV infection. Contrarily, the role of the genes in OLP-HCV+ve patients remains unclear and might warrant further researches.

Publication metadata

Author(s): Carrozzo M, Elia A, Mereu V, Dametto E, Fasano ME, Broccoletti R, Rendine S, Amoroso A

Publication type: Article

Publication status: Published

Journal: Oral Diseases

Year: 2011

Volume: 17

Issue: 3

Pages: 309-313

Print publication date: 23/09/2010

ISSN (print): 1354-523X

ISSN (electronic): 1601-0825

Publisher: Wiley-Blackwell Publishing, Inc.

URL: http://dx.doi.org/10.1111/j.1601-0825.2010.01742.x

DOI: 10.1111/j.1601-0825.2010.01742.x

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