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Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men

Lookup NU author(s): Dr Catherine Meplan, Professor John Hesketh

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Abstract

Background: Evidence for an association between selenium status and prostate cancer risk is still inconclusive. Anticarcinogenic effects of selenium are supposedly mediated through cellular protective and redox properties of selenoenzymes in vivo. We evaluated the association between serum selenium status and prostate cancer risk in a population with relative low selenium concentrations considering effect modification by genetic variants in selenoprotein genes. Materials and Methods: A case-control study of 248 incident prostate cancer cases and 492 matched controls was nested within the EPIC-Heidelberg cohort. Baseline blood samples were analyzed for serum selenium and selenoprotein P concentrations and glutathione peroxidase activity. Genotyping was carried out for SEP15 (rs5859, rs540049), SEPP1 (rs3877899, rs7579), GPX1 (rs1050450), and GPX4 (rs713041). Conditional logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Results: The OR for prostate cancer was 0.89 (95% CI, 0.79-1.01) per 10 μg/L increase of serum selenium concentration. This association was modified by rs1050450 (C>T) in GPX1 (Pinteraction = 0.03), with carriers of one or two T alleles having a significantly reduced OR of 0.87 (95% CI, 0.76-0.99). Furthermore, there was an association between rs7579 genotype in SEPP1 and prostate cancer risk (OR, 1.72; 95% CI, 0.99-2.98). Conclusions: Our results support a role of selenium and polymorphisms in selenoenzymes in prostate cancer etiology, which warrants confirmation in future studies. Impact: These findingsmight help to explain biological effects of selenium in prostate cancer development in order to overcome inconsistencies arising from former studies. ©2010 AACR.

Publication metadata

Author(s): Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, Åkesson B, Rohrmann S, Linseisen J

Publication type: Article

Publication status: Published

Journal: Cancer Epidemiology Biomarkers and Prevention

Year: 2010

Volume: 19

Issue: 11

Pages: 2958-2968

Print publication date: 17/09/2010

ISSN (print): 1055-9965

ISSN (electronic): 1538-7755

Publisher: American Association for Cancer Research

URL: http://dx.doi.org/10.1158/1055-9965.EPI-10-0364

DOI: 10.1158/1055-9965.EPI-10-0364

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