Toggle Main Menu Toggle Search

Open Access padlockePrints

Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: Preliminary analysis of the results of the IMPACT study

Lookup NU author(s): Dr Fiona Douglas

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

OBJECTIVE: To evaluate the role of targeted prostate cancer screening in men with BRCA1 or BRCA2 mutations, an international study, IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls), was established. This is the first multicentre screening study targeted at men with a known genetic predisposition to prostate cancer. A preliminary analysis of the data is reported. PATIENTS AND METHODS Men aged 40-69 years from families with BRCA1 or BRCA2 mutations were offered annual prostate specific antigen (PSA) testing, and those with PSA >3 ng/mL, were offered a prostate biopsy. Controls were men age-matched (± 5 years) who were negative for the familial mutation. RESULTS In total, 300 men were recruited (205 mutation carriers; 89 BRCA1, 116 BRCA2 and 95 controls) over 33 months. At the baseline screen (year 1), 7.0% (21/300) underwent a prostate biopsy. Prostate cancer was diagnosed in ten individuals, a prevalence of 3.3%. The positive predictive value of PSA screening in this cohort was 47·6% (10/21). One prostate cancer was diagnosed at year 2. Of the 11 prostate cancers diagnosed, nine were in mutation carriers, two in controls, and eight were clinically significant. CONCLUSIONS The present study shows that the positive predictive value of PSA screening in BRCA mutation carriers is high and that screening detects clinically significant prostate cancer. These results support the rationale for continued screening in such men. © 2010 BJU International.


Publication metadata

Author(s): Mitra A, Bancroft E, Barbachano Y, Page E, Foster C, Jameson C, Mitchell G, Lindeman G, Stapleton A, Suthers G, Evans D, Cruger D, Blanco I, Mercer C, Kirk J, Maehle L, Hodgson S, Walker L, Izatt L, Douglas F, Tucker K, Dorkins H, Clowes V, Male A, Donaldson A, Brewer C, Doherty R, Bulman B, Osther P, Salinas M, Eccles D, Axcrona K, Jobson I, Newcombe B, Cybulski C, Rubinstein W, Buys S, Townshend S, Friedman E, Domchek S, Ramon Y Cajal T, Spigelman A, Teo S, Nicolai N, Aaronson N, Ardern-Jones A, Bangma C, Dearnaley D, Eyfjord J, Falconer A, Grönberg H, Hamdy F, Johannsson O, Khoo V, Kote-Jarai Z, Lilja H, Lubinski J, Melia J, Moynihan C, Peock S, Rennert G, Schröder F, Sibley P, Suri M, Wilson P, Bignon Y, Strom S, Tischkowitz M, Liljegren A, Ilencikova D, Abele A, Kyriacou K, Van Asperen C, Kiemeney L, Easton D, Eeles R

Publication type: Article

Publication status: Published

Journal: BJU International

Year: 2011

Volume: 107

Issue: 1

Pages: 28-39

Print publication date: 14/09/2010

ISSN (print): 1464-4096

ISSN (electronic): 1464-410X

Publisher: Wiley-Blackwell Publishing Ltd.

URL: http://dx.doi.org/10.1111/j.1464-410X.2010.09648.x

DOI: 10.1111/j.1464-410X.2010.09648.x


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
Central Manchester Foundation Trust
Jack and Judy Baker
Ronald and Rita McAulay Foundation
NIHR
Royal Marsden NHS Foundation Trust
400048Cancer Councils of Victoria and South Australia
C1287/A10118Cancer Research UK
C1287/A8874Cancer Research UK
C5047/A8385Cancer Research UK
PCFA PRO4Prostate Cancer Foundation of Australia

Share