Cellular mechanisms of high frequency oscillations in epilepsy: on the diverse sources of pathological activities

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  2. Professor Andrew Trevelyan
Author(s)Prida L, Trevelyan AJ
Publication type Review
JournalEpilepsy Research
ISSN (print)0920-1211
ISSN (electronic)1872-6844
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A major goal in epilepsy research is to understand the cellular basis of pathological forms of network oscillations, particularly those classified as high-frequency activity. What are the underlying mechanisms, and how do they arise? The topic of this review is the pattern of high-frequency oscillations that have been recorded in epileptic tissue, and how they might differ from physiological activity. We discuss recent experimental and clinical data with a major focus on the diverse sources of extracellular signals and the contribution of different neuronal populations, including GABAergic interneurons and glutamatergic principal cells.
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