Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study

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  2. Dr Ahmad Khundakar
  3. Dr Christopher Morris
  4. Arthur Oakley
  5. Professor Alan Thomas
Author(s)Khundakar AA, Morris CM, Oakley AE, Thomas AJ
Publication type Article
JournalPsychiatry Research: Neuroimaging
ISSN (print)0925-4927
ISSN (electronic)1872-7506
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Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.
PublisherElsevier Ireland Ltd
PubMed id21924875
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