Cellular pathology within the anterior cingulate cortex of patients with late-life depression: A morphometric study
- Lookup NU author(s)
- Dr Ahmad Khundakar
- Dr Christopher Morris
- Arthur Oakley
- Dr Alan Thomas
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| Author(s) | | Khundakar AA, Morris CM, Oakley AE, Thomas AJ |
| Publication type | | Article |
| Journal | | Psychiatry Research: Neuroimaging |
| Year | | 2011 |
| Volume | | 194 |
| Issue | | 2 |
| Pages | | 184-189 |
| ISSN (print) | | 0925-4927 |
| ISSN (electronic) | | 1872-7506 |
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| Full text for this publication is not currently held within this repository. Alternative links are provided below where available. |
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| Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression. |
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| Publisher | | Elsevier Ireland Ltd |
| URL | | http://dx.doi.org/10.1016/j.pscychresns.2011.04.008 |
| DOI | | 10.1016/j.pscychresns.2011.04.008 |
| PubMed id | | 21924875 |
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