Self-Organisation of Self-Complementary DNA Molecules Covalently Attached to Silicon Surfaces

  1. Lookup NU author(s)
  2. Dr Rebeca Gonzalez
  3. Dr Samson Patole
  4. Professor Bernard Connolly
  5. Professor Andrew Houlton
  6. Dr Ben Horrocks
  7. Dr Andrew Pike
Author(s)Carlsson S, Gonzalez R, O'Farrell N, Patole SN, Connolly BA, Houlton A, Horrocks BR, Pike A
Publication type Article
JournalScience of Advanced Materials
ISSN (print)1947-2935
ISSN (electronic)1947-2943
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Self-complementary oligonucleotides were synthesized at atomically-flat Si(111) surfaces and their hybridization reaction was studied using atomic force microscopy. Annealing these surfaces in aqueous media, in the absence of any other reagents or DNA, resulted in a self-organization process in which hybridization produced well-defined features in the AFM images. By varying the surface coverage of DNA we provide evidence that the features observed are due to inter-strand rather than intra-strand hybridization reactions.
PublisherAmerican Scientific Publishers
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