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Cyclin-dependent kinases: inhibition and substrate recognition

Lookup NU author(s): Professor Jane Endicott, Professor Martin NobleORCiD, Dr Julie Tucker

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Abstract

Four unresolved issues of cyclin-dependent kinase (CDK) regulation have been addressed by structural studies this year - the mechanism of CDK inhibition by members of the INK4 family of CDK inhibitors, consensus substrate sequence recognition by CDKs, the role of the cyclin subunit in substrate recognition and the structural mechanism underlying CDK inhibition by phosphorylation.

Publication metadata

Author(s): Endicott JA, Noble MEM, Tucker JA

Publication type: Article

Publication status: Published

Journal: Current Opinion in Structural Biology

Year: 1999

Volume: 9

Issue: 6

Pages: 738-744

ISSN (print): 0959-440X

ISSN (electronic): 1879-033X

Publisher: Elsevier Ltd

URL: http://dx.doi.org/10.1016/S0959-440X(99)00038-X

DOI: 10.1016/S0959-440X(99)00038-X

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